Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film.

The increasing prevalence of implant-associated infections (IAI) in orthopedics remains a public health challenge. Calcium phosphates (CaPs) are critical biomaterials in dental treatments and bone regeneration. It is highly desirable to endow CaPs with antibacterial properties.

Osteogenic, Angiogenic, and Antibacterial Bioactive Nano-Hydroxyapatite Co-Synthesized Using γ-Polyglutamic Acid and Copper.

Nano-antibacterial calcium phosphate (CaP) has attracted intense attention with regard to its wide variety of medical and biological applications. The γ-polyglutamic acid and copper cosynthesized hydroxyapatite (γ-PGA/CuHAp) was synthesized using the wet method. Structural and chemical characterizations demonstrate that copper was quantitatively incorporated into the hydroxyapatite structure, and the degree of Cu substitution was up to 20 mol % in the synthesized nanocrystals.