FAIR Data Cube, a FAIR data infrastructure for integrated multi-omics data analysis.

Motivation: We are witnessing an enormous growth in the amount of molecular profiling (-omics) data. The integration of multi-omics data is challenging. Moreover, human multi-omics data may be privacy-sensitive and can be misused to de-anonymize and (re-)identify individuals.

Examining macro-level traffic crashes considering nonlinear and spatiotemporal spillover effects.

Understanding the impacts of traffic crashes is essential for safety management and proactive safety protection. Current studies often hold the assumption of linearity and spatial dependence, which may lead to underestimated results. To address these gaps, this study considers both nonlinear and spatiotemporal spillover effects to explore the intricate relationships between vehicular crashes and their influencing factors at a macro level.

A Polymeric Two-in-One Electron Transport Layer and Transparent Electrode for Efficient Indoor All-Organic Solar Cells.

Transparent electrodes (TEs) are vital in optoelectronic devices, enabling the interaction of light and charges. While indium tin oxide (ITO) has traditionally served as a benchmark TE, its high cost prompts the exploration of alternatives to optimize electrode characteristics and improve device efficiencies. Conducting polymers, which combine polymer advantages with metal-like conductivity, emerge as a promising solution for TEs.

A Highly Conductive -Type Conjugated Polymer Synthesized in Water.

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a benchmark hole-transporting (-type) polymer that finds applications in diverse electronic devices. Most of its success is due to its facile synthesis in water, exceptional processability from aqueous solutions, and outstanding electrical performance in ambient. Applications in fields like (opto-)electronics, bioelectronics, and energy harvesting/storage devices often necessitate the complementary use of both -type and -type (electron-transporting) materials.

Photocatalytic doping of organic semiconductors.

Chemical doping is an important approach to manipulating charge-carrier concentration and transport in organic semiconductors (OSCs) and ultimately enhances device performance. However, conventional doping strategies often rely on the use of highly reactive (strong) dopants, which are consumed during the doping process. Achieving efficient doping with weak and/or widely accessible dopants under mild conditions remains a considerable challenge.

[Construction of ecological network with protected areas as the main region in Guangzhou City, China].

In the context of the national ecological security development strategy, constructing regional ecological networks centered on protected areas and ecological corridors has become an urgent issue in protected areas system development of China. We focused on strengthening ecological connections between protected areas in Guangzhou, identified the ecological resource patches, ecological corridors, and ecological nodes by using Invest model, connectivity analysis, circuit theory models, and graph-theoretical network structure evaluation, and constructed an ecological network for the Guangzhou with nature reserves as the core. The results showed that 52 ecological resource patches were identified in the study area, covering a total area of 1450.

Ground-state electron transfer in all-polymer donor:acceptor blends enables aqueous processing of water-insoluble conjugated polymers.

Water-based conductive inks are vital for the sustainable manufacturing and widespread adoption of organic electronic devices. Traditional methods to produce waterborne conductive polymers involve modifying their backbone with hydrophilic side chains or using surfactants to form and stabilize aqueous nanoparticle dispersions. However, these chemical approaches are not always feasible and can lead to poor material/device performance.

Mechanically and Thermally Stable Cathode Electrolyte Interphase Enables High-temperature, High-voltage Li||LiCoO Batteries.

The development of high-energy-density Li||LiCoO batteries is severely limited by the instability of cathode electrolyte interphase (CEI) at high voltage and high temperature. Here we propose a mechanically and thermally stable CEI by electrolyte designing for achieving the exceptional performance of Li||LiCoO batteries at 4.6 V and 70 °C.

Stable organic electrochemical neurons based on p-type and n-type ladder polymers.

Organic electrochemical transistors (OECTs) are a rapidly advancing technology that plays a crucial role in the development of next-generation bioelectronic devices. Recent advances in p-type/n-type organic mixed ionic-electronic conductors (OMIECs) have enabled power-efficient complementary OECT technologies for various applications, such as chemical/biological sensing, large-scale logic gates, and neuromorphic computing. However, ensuring long-term operational stability remains a significant challenge that hinders their widespread adoption.

Constructing Highly Li Conductive Electrode Electrolyte Interphases for 4.6 V Li||LiCoO Batteries via Electrolyte Additive Engineering.

To improve voltage is considered to effectively address the energy-density question of Li||LiCoO batteries. However, it is restricted by the instability of electrode electrolyte interphases in carbonate electrolytes, which mainly originates from Li dendrite growth and structural instability of LiCoO at high voltage. Herein, an electrolyte additive strategy is proposed for constructing efficient LiN O -contained cathode electrolyte interphase for 4.

Dimensional Reduction of Metal-Organic Frameworks for Enhanced Cryopreservation of Red Blood Cells.

To increase the red blood cell (RBC) cryopreservation efficiency by metal-organic frameworks (MOFs), a dimensional reduction approach has been proposed. Namely, 3D MOF nanoparticles are progressively reduced to 2D ultra-thin metal-organic layers (MOLs). We found that 2D MOLs are beneficial for enhanced interactions of the interfacial hydrogen-bonded water network and increased utilization of inner ordered structures, due to the higher surface-to-volume ratio.

Ion-tunable antiambipolarity in mixed ion-electron conducting polymers enables biorealistic organic electrochemical neurons.

Biointegrated neuromorphic hardware holds promise for new protocols to record/regulate signalling in biological systems. Making such artificial neural circuits successful requires minimal device/circuit complexity and ion-based operating mechanisms akin to those found in biology. Artificial spiking neurons, based on silicon-based complementary metal-oxide semiconductors or negative differential resistance device circuits, can emulate several neural features but are complicated to fabricate, not biocompatible and lack ion-/chemical-based modulation features.

Lithium Hexamethyldisilazide Endows Li||NCM811 Battery with Superior Performance.

The construction of stable cathode electrolyte interphase (CEI) is the key to improve the NCM811 particle structure and interfacial stability via electrolyte engineering. In He's work, lithium hexamethyldisilazide (LiHMDS) as the electrolyte additive is proposed to facilitate the generation of stable CEI on NCM811 cathode surface and eliminate HO and HF in the electrolyte at the same time, which boosts the cycling performance of Li||NCM811 battery up to 1000 or 500 cycles with 4.5 V cut-off voltage at 25 or 60 °C.

A sensitive and accurate GC-MS method for analyzing microbial metabolites short chain fatty acids and their hydroxylated derivatives in newborn fecal samples.

Short chain fatty acids (SCFAs), crucial intestinal bacterial metabolites, have been widely accepted as potential diagnostic markers in neonatal medicine. Nevertheless, it is still a great challenge to accurately quantify SCFAs in newborn fecal samples due to the huge variation of water content, limited commercial isotope-labeled internal standards and poor sensitivity. In this study, NaCO solution (50 μg/mL) was applied to convert the free SCFAs to SCFA sodium salts, which could prevent the loss of violate SCFAs during lyophilization process.

Highly Oxidation-Resistant Electrolyte for 4.7 V Sodium Metal Batteries Enabled by Anion/Cation Solvation Engineering.

Sodium metal batteries (SMBs) are considered as promising battery system due to abundant Na sources. However, poor compatibility between electrolyte and cathode severely impedes its development. Herein, we proposed an anion/cation solvation strategy for realizing 4.

Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis.

Background: Emerging evidence suggests that exercise is a simple and effective method for maintaining brain function.

Aims: This review evaluates the effects of five physical exercises, including aerobic training (AT), high-intensity interval training (HIIT), combined training (CT), resistance training (RT), and AT+RT, on the serum level of brain-derived neurotrophic factor (BDNF) in healthy and non-healthy populations.

Methods: We searched CNKI, PubMed, Embase, Scopus, Medline, Web of Science, and Cochrane Library databases to review randomized controlled studies on exercise interventions for BDNF.

Dual-Stage Irradiation of Size-Switchable Albumin Nanocluster for Cascaded Tumor Enhanced Penetration and Photothermal Therapy.

The triple-negative breast cancer (TNBC) microenvironment makes a feature of aberrant vasculature, high interstitial pressure, and compact extracellular matrix, which combine to reduce the delivery and penetration of therapeutic agents, bringing about incomplete elimination of cancer cells. Herein, employing the tumor penetration strategy of size-shrinkage combined with ligand modification, we constructed a photothermal nanocluster for cascaded deep penetration in tumor parenchyma and efficient eradication of TNBC cells. In our approach, the photothermal agent indocyanine green (ICG) is laded in human serum albumin (HSA), which is cross-linked by a thermally labile azo linker (VA057) and then further modified with a tumor homing/penetrating tLyP-1 peptide (HP), resulting in a TNBC-targeting photothermal-responsive size-switchable albumin nanocluster (ICG@HSA-Azo-HP).

Formation of NaF-Rich Solid Electrolyte Interphase on Na Anode through Additive-Induced Anion-Enriched Structure of Na Solvation.

High-capacity sodium (Na) anodes suffer from dendrite growth due to the high reactivity, which can be overcome through inducing a stable NaF-rich solid electrolyte interphase (SEI). Herein, we propose an additive strategy for realizing the anion-enriched structure of Na solvation to obtain a NaF-rich SEI. The electron-withdrawing acetyl group in 4-acetylpyridine (4-APD) increases the coordination number of PF in the Na solvation sheath to facilitate PF to decompose into NaF.

Separator-Wetted, Acid- and Water-Scavenged Electrolyte with Optimized Li-Ion Solvation to Form Dual Efficient Electrode Electrolyte Interphases via Hexa-Functional Additive.

The performance of lithium metal batteries (LMBs) is determined by many factors from the bulk electrolyte to the electrode-electrolyte interphases, which are crucially affected by electrolyte additives. Herein, the authors develop the heptafluorobutyrylimidazole (HFBMZ) as a hexa-functional additive to inhibit the dendrite growth on the surface of lithium (Li) anode, and then improve the cycling performance and rate capabilities of Li||LiNi Co Mn O (NCM622). The HFBMZ can remove the trace H O and HF from the electrolyte, reducing the by-products on the surface of solid electrolyte interphase (SEI) and inhibiting the dissolution of metal ions from NCM622.

Additive-Assisted Hydrophobic Li -Solvated Structure for Stabilizing Dual Electrode Electrolyte Interphases through Suppressing LiPF Hydrolysis.

Lithium-metal batteries have attracted much attention due to their high energy density. However, the hydrolysis of LiPF leads to uncontrollable Li dendrites growth and fast capacity fading. Herein, a hydrophobic Li -solvated structure is designed by inducing the hexafluoroisopropyl acrylate into the electrolyte system.

Advanced Nanomaterials-Assisted Cell Cryopreservation: A Mini Review.

Cell cryopreservation is of vital significance both for transporting and storing cells before experimental/clinical use. Cryoprotectants (CPAs) are necessary additives in the preserving medium in cryopreservation, preventing cells from freeze-thaw injuries. Traditional organic solvents have been widely used in cell cryopreservation for decades.

Optimizing Electrode/Electrolyte Interphases and Li-Ion Flux/Solvation for Lithium-Metal Batteries with Qua-Functional Heptafluorobutyric Anhydride.

The safety and electrochemical performance of rechargeable lithium-metal batteries (LMBs) are primarily influenced by the additives in the organic liquid electrolytes. However, multi-functional additives are still rarely reported. Herein, we proposed heptafluorobutyric anhydride (HFA) as a qua-functional additive to optimize the composition and structure of the solid electrolyte interphase (SEI) at the electrode/electrolyte interface.

Risk Assessment of the Dietary Phosphate Exposure in Taiwan Population Using a Total Diet Study.

Phosphorus and calcium are essential nutrients for the human body. However, excessive intake of phosphates and a low calcium:phosphorus ratio can lead to disorders in calcium-phosphorus metabolism, kidney disease, or osteoporosis. In this study, a total diet study (TDS) was used.

A Kinect-based system for physical rehabilitation: a pilot study for young adults with motor disabilities.

This study assessed the possibility of rehabilitating two young adults with motor impairments using a Kinect-based system in a public school setting. This study was carried out according to an ABAB sequence in which A represented the baseline and B represented intervention phases. Data showed that the two participants significantly increased their motivation for physical rehabilitation, thus improving exercise performance during the intervention phases.

(1E,4E)-1,5-Bis(2,6-difluoro-phen-yl)penta-1,4-dien-3-one.

The mol-ecule of the title compound, C(17)H(10)F(4)O, is roughly planar, with a dihedral angle of 5.59 (14)° between the two phenyl rings. The mol-ecule has an E conformation with respect to the olefinic bonds.