Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.

Disrupted neonatal lung angiogenesis and alveologenesis often give rise to bronchopulmonary dysplasia (BPD), the most common chronic lung disease in children. Hyperoxia-induced pulmonary vascular and alveolar damage in premature infants is one of the most common and frequent factors contributing to BPD. The purpose of the present study was to explore the key molecules and the underlying mechanisms in hyperoxia-induced lung injury in neonatal mice and to provide a new strategy for the treatment of BPD.

Value of heparin-binding protein in the diagnosis of severe infection in children: a prospective study.

Objectives: To study the value of heparin-binding protein (HBP) in the diagnosis of severe infection in children.

Methods: This study was a prospective observational study. The medical data of children who were admitted to the pediatric intensive care unit due to infection from January 2019 to January 2020 were collected.

Theoretical derivation of slip boundary conditions for single-species gas and binary gas mixture.

A theoretical derivation of slip boundary conditions for single-species gas and binary gas mixture based on two typical gas-surface scattering kernels is presented. If the Maxwell model is assumed, then the derived slip boundary conditions are consistent with the previous conclusions. Considering the limitation of the Maxwell model in describing the complexity of gas-surface scattering behavior, we further perform theoretical analyses based on the Cercignani-Lampis-Lord (CLL) model, where separate accommodation coefficients in the tangential and normal directions are defined.

Enhancement of toughness of SiC through compositing SiC-Al interpenetrating phase composites.

Silicon carbide has excellent properties such as high hardness and decomposition temperature, but its applications are limited by its poor toughness. Here, we investigate the enhancement of SiC's toughness by compositing silicon carbide-aluminum (SiC-Al) interpenetrating phase composites (IPCs) via molecular dynamics simulations. IPCs are a class of composites consisting of two or more phases that are topologically continuous and three-dimensionally interconnected through the microstructure.

Nonlinear diffusion, bonding, and mechanics of the interface between austenitic steel and iron.

We investigate the atomic diffusivity and mechanics of the interface between bulk austenitic steel (fcc structure) and bcc iron at various temperatures and strain rates using molecular dynamics simulations. We adopt the system of FeCrNi corresponding to 316L steel as a representative model of austenitic steels, denoted as FeCrNi. We find that the compressive strength of the FeCrNi/Fe system decreases by 44.