Green Synthesis of Au-NPs on g-CN Hybrid Nanomaterials Based on Supramolecular Pillar[6]arene and Its Applications for Catalysis.

Gold nanoparticles (Au NPs) are installed in situ on the surfaces of graphitic carbon nitride (g-CN) based on supramolecular hydroxylatopillar[6]arene (P6). The Au NPs can be obtained via the redox reaction between HAuCl and P6 without any NH-NH, NaBH, and other reductants, where AuCl is reduced to Au by the -OH groups in the presence of OH, and the -OH groups are oxidized into -COOH. First, P6 is loaded onto the surface of g-CN via π-π interaction between P6 and g-CN, which offers a stabilized and reduced site for in situ anchoring of Au NPs.

Replicated risk variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.

Genome-wide association studies (GWASs) have reported numerous associations between risk variants and major psychiatric disorders (MPDs) including schizophrenia (SCZ), bipolar disorder (BPD), major depressive disorder (MDD) and others. We reviewed all of the published GWASs, and extracted the genome-wide significant (p<10) and replicated associations between risk SNPs and MPDs. We found the associations of 6 variants located in 6 genes, including L type voltage-gated calcium channel (LTCCs) subunit alpha1 C gene (), that were genome-wide significant ( ) and replicated at single-point level across at least two GWASs.