Synergistic promotion mechanism and structure-function relationship of nonmetallic atoms doped carbon nanodots driving Tagetes patula L. to remediate cadmium-contaminated soils.

Phytoremediation is an economical and effective strategy to remove cadmium (Cd) from polluted environments. To improve its efficiency, nanotechnology has been proposed to collaborate with hyperaccumulators in the remediation of Cd-polluted soils. However, the intricate structure-function relationship and the underlying regulatory mechanisms by which nanomaterials regulate Cd migration and conversion within the soil-plant system remained unrevealed.

Erratum: Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma: Erratum.

[This corrects the article DOI: 10.7150/ijbs.54014.

Relationship between Nitrogen Dynamics and Key Microbial Nitrogen-Cycling Genes in an Intensive Freshwater Aquaculture Pond.

Intensive aquaculture in high-density hybrid snakehead [ (♀) × (♂)] fishponds can lead to toxic conditions for fish. This study investigated nitrogen migration and transformation in these fishponds during different cultivation periods. Using qPCR technology, we analyzed the abundance variation of nitrogen-cycling microorganisms in water and sediment to reveal the nitrogen metabolism characteristics of hybrid snakehead fishponds.

Isolation of a novel multiple-heavy metal resistant Lampropedia aestuarii GYF-1 and investigation of its bioremediation potential.

Background: Heavy metal contamination has been a severe worldwide environmental issue. For industrial pollutions, heavy metals rarely exist as singular entities. Hence, researches have increasingly focused on the detrimental effect of mixed heavy metal pollution.

Isopsoralen promotes osteogenic differentiation of human jawbone marrow mesenchymal cells through Notch signaling pathway.

Background: The aim of this study was to investigate the effect of isopsoralen on osteogenic differentiation of human jawbone marrow mesenchymal cells and its possible mechanism.

Method: The cytotoxicity and proliferation of cells were measured by a cell counting kit 8. Alkaline phosphatase activity analysis was then used to determine the optimal concentration of isopsoralen to promote the differentiation.

TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.

Background: Drug resistance limits the treatment effect of cisplatin-based chemotherapy in head and neck squamous cell carcinoma (HNSCC), and the underlying mechanism is not fully understood. The aim of this study was to explore the cause of cisplatin resistance in HNSCC.

Methods: We performed survival and gene set variation analyses based on HNSCC cohorts and identified the critical role of tumor necrosis factor alpha-induced protein 2 (TNFAIP2) in cisplatin-based chemotherapy resistance.

Bayesian-Optimized Hybrid Kernel SVM for Rolling Bearing Fault Diagnosis.

We propose a new fault diagnosis model for rolling bearings based on a hybrid kernel support vector machine (SVM) and Bayesian optimization (BO). The model uses discrete Fourier transform (DFT) to extract fifteen features from vibration signals in the time and frequency domains of four bearing failure forms, which addresses the issue of ambiguous fault identification caused by their nonlinearity and nonstationarity. The extracted feature vectors are then divided into training and test sets as SVM inputs for fault diagnosis.

Mitophagy in ototoxicity.

Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways. The results of ototoxicity models indicate the importance of this process in the etiology of ototoxicity.

Development and validation of a nomogram to predict occult cervical metastasis in early oral squamous cell carcinoma.

Background: Lack of adequate objectivity and universality, available models are still difficult to be applied to clinical practice in predicting occult cervical metastasis of early oral squamous cell carcinoma (OSCC). Taking abnormal metabolic state into consideration, the current model is helpful to distinguish those patients with or without occult cervical metastasis.

Methods: This study retrospectively analyzed 330 OSCC patients initially diagnosed cT1-2N0M0 stage and received neck dissection from January 2020 to July 2022.

Effective and Low-Cost In Situ Surface Engineering Strategy to Enhance the Interface Stability of an Ultrahigh Ni-Rich NCMA Cathode.

Ultrahigh Ni-rich quaternary layered oxides LiNiCoMnAlO (1 - - - ≥ 0.9) are regarded as some of the most promising cathode candidates for lithium-ion batteries (LIBs) because of their high energy density and low cost. However, poor rate capacity and cycling performance severely limit their further commercial applications.

Rolling Bearing Fault Diagnosis Based on WGWOA-VMD-SVM.

A rolling bearing fault diagnosis method based on whale gray wolf optimization algorithm-variational mode decomposition-support vector machine (WGWOA-VMD-SVM) was proposed to solve the unclear fault characterization of rolling bearing vibration signal due to its nonlinear and nonstationary characteristics. A whale gray wolf optimization algorithm (WGWOA) was proposed by combining whale optimization algorithm (WOA) and gray wolf optimization (GWO), and the rolling bearing signal was decomposed by using variational mode decomposition (VMD). Each eigenvalue was extracted as eigenvector after VMD, and the training and test sets of the fault diagnosis model were divided accordingly.

Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas.

Background: Previous studies have suggested an important role for N6-methyladenosine (m6A) modification in the proliferation of glioma cells. N6, 2'-O-dimethyladenosine (m6Am) is another methylated form affecting the fate and function of most RNA. PCIF1 has recently been identified as the sole m6Am methyltransferase in mammalian mRNA.

Dendrobium officinale polysaccharides attenuate uropathogenic Escherichia coli (UPEC)-induced pyroptosis in macrophage cells.

Urinary tract infections (UTI) are recognized as one of the most common infectious diseases worldwide, and uropathogenic Escherichia coli (UPEC) is the main causative agent of UTI. Dendrobium officinale polysaccharides (DOPs), the main effective ingredient in Dendrobium officinale, have been reported to possess an anti-inflammatory role. Whether DOPs can attenuate the inflammatory injury (pyroptosis) induced by UPEC remains unknown.

Regulation of Semaphorin3A in the process of cutaneous wound healing.

Semaphorin 3A (Sema3A) has been recognized as a crucial regulator of morphogenesis and homeostasis over a wide range of organ systems. However, its function in cutaneous wound healing is poorly understood. In our study, we demonstrated that Sema3A adenovirus plasmids transfection limited keratinocyte proliferation and decreased migrative capacity as assessed by in vitro wound healing assay.

Identification of Biomarkers Related to Regulatory T Cell Infiltration in Oral Squamous Cell Carcinoma Based on Integrated Bioinformatics Analysis.

Background: Oral squamous cell carcinoma (OSCC) is one of the most prevalent malignancies worldwide. More recently, the administration of immune checkpoint inhibitors has opened up more possibilities for cancer treatment.

Methods: We utilized a weighted gene co-expression network and the single sample gene set enrichment analysis (ssGSEA) algorithm in the TCGA database and identified a module highly correlated with regulatory T cell (Treg) abundance in OSCC.

Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway.

Background: Eukaryotic translation initiation factor 6 (eIF6), also known as integrin β4 binding protein, is involved in ribosome formation and mRNA translation, acting as an anti-association factor. It is also essential for the growth and reproduction of cells, including tumor cells. Yet, its role in oral squamous cell carcinoma (OSCC) remains unclear.

A novel biphenyl diester derivative, AB38b, inhibits glioblastoma cell growth via the ROS-AKT/mTOR pathway.

AB38b is a novel biphenyl diester derivative synthesized in our laboratory, and it has been shown to improve the pathology of nephropathy and encephalopathy in diabetic mice. Glioblastoma (GBM) is the most lethal brain tumor, without effective drugs to date. The present study aims at investigating the role of AB38b in GBM growth and revealing the underlying molecular mechanisms.

Impact Fretting Wear of MoS/C Nanocomposite Coating with Different Carbon Contents under Cycling Low Kinetic Energy.

MoS/C nanocomposite coatings were deposited on a 304 stainless steel plate by unbalanced magnetron sputtering from carbon and molybdenum disulfide targets, and the target current of MoS was varied to prepare for coating with different carbon contents. The mechanical and tribological properties of the MoS/C nanocomposite coating with different carbon contents were studied using a low-velocity impact wear machine based on kinetic energy control, and the substrate was used as the comparison material. The atomic content ratio of Mo to S in the MoS/C coating prepared by unbalanced magnetron sputtering was approximately 1.

Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits.

Objective: In the present study, we intend to assess the function of Sema3A in osteointegration of titanium implants both in vivo and in vitro.

Material And Methods: Briefly, Sema3A was transfected in HBMSCs cells to detect its effect on osteogenesis. Subsequently, an in vivo rabbit model was established.

[Investigation of Soil Fungal Communities and Functionalities within Karst Paddy Fields].

Fungi are important drivers of soil biogeochemical cycles. However, the characteristics of fungal community structures and functional groups within karst area (KA) soils remain understudied. Top soil samples were collected from paddy fields within a KA and non-karst area (NKA) containing red soil, in the Maocun karst experimental site of Guilin.

Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling.

Ubiquitin D (UBD) is highly upregulated in many cancers, and plays a pivotal role in the pathophysiological processes of cancers. However, its roles and underlying mechanisms in oral squamous cell carcinoma (OSCC) are still unclear. In the present study, we investigated the role of UBD in patients with OSCC.

Antiaging compounds from marine organisms.

Marine organisms have received mounting attention in antiaging activity due to their exclusive chemicals. This review aims at revealing and discussing prospective antiaging substance from marine macroalgae, micaroalgae, invertebrate and vertebrate. The activity and mechanism of the carbohydrate, protein, pigment, flavonoids, fatty acids, phenols from marine organisms were revealed through a variety of antiaging experimental models such as rats, Drosophila melanogaster and Caenorhabditis elegans.

Autotransplantation of a completely developed impacted maxillary canine: A 7-year follow-up case report.

Background: Impacted maxillary canines are likely to be extracted in adult patients once orthodontic treatment is ruled out. The missing teeth are generally replaced with dental implants.

Case Description: The authors report the clinical case of a 45-year-old man who was missing the maxillary left canine for 30 years.