Publications by authors named "Junbo Si"
The constant mutation of SARS-CoV-2 has led to the continuous appearance of viral variants and their pandemics and has improved the development of vaccines with a broad spectrum of antigens to curb the spread of the virus. The work described here suggested a novel vaccine with a virus-like structure (VLS) composed of combined mRNA and protein that is capable of stimulating the immune system in a manner similar to that of viral infection. This VLS vaccine is characterized by its ability to specifically target dendritic cells and/or macrophages through S1 protein recognition of the DC-SIGN receptor in cells, which leads to direct mRNA delivery to these innate immune cells for activation of robust immunity with a broad spectrum of neutralizing antibodies and immune protective capacity against variants.
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- - A new lipid nanoparticle system has been developed to deliver antigens like mRNA and proteins more effectively, designed to mimic virus-like structures for better immune response, particularly against SARS-CoV-2 variants.
- - This system incorporates the S1 protein from the Omicron variant to help deliver mRNA from a newer variant, enhancing the interaction with immune receptors and boosting the immune response.
- - Research shows that combining protein and mRNA in this delivery method results in a stronger antibody response in mice, suggesting that it activates various immune cell types and improves overall immunity.