Effects of Extracellular Matrix Changes Induced by a High-Fat Diet on Gallbladder Smooth Muscle Dysfunction.

Background: Gallstone formation is a common digestive ailment, with unclear mechanisms underlying its development. Dysfunction of the gallbladder smooth muscle (GSM) may play a crucial role, particularly with a high-fat diet (HFD). This study aimed to investigate the effects of an HFD on GSM and assess how it alters contractility through changes in the extracellular matrix (ECM).

Injectable Hydrogels Including Magnetic Nanosheets for Multidisciplinary Treatment of Hepatocellular Carcinoma via Magnetic Hyperthermia.

Relapse and unresectability have become the main obstacle for further improving hepatocellular carcinoma (HCC) treatment effect. Currently, single therapy for HCC in clinical practice is limited by postoperative recurrence, intraoperative blood loss and poor patient outcomes. Multidisciplinary therapy has been recognized as the key to improving the long-term survival rate for HCC.

Stable and Label-Free Fluorescent Probe Based on G-triplex DNA and Thioflavin T.

G-triplexes have recently been identified as a new kind of DNA structures. They perhaps possess specific biological and chemical functions similar as identified G-quadruplex but can be formed by shorter G-rich sequences with only three G-tracts. However, until now, limited G-triplexes sequences have been reported, which might be due to the fact that their stability is one of the biggest concerns during their functional studies and application research.

β-Ni(OH) nanosheets: an effective sensing platform for constructing nucleic acid-based optical sensors.

In this study, beta nickel hydroxide (β-Ni(OH)) nanosheets, one of the transition metal oxyhydroxides with two dimensional (2D) structures, were explored as a new fluorescent biosensor platform and applied in constructing optical sensors for bioanalysis. It was found that β-Ni(OH) nanosheets displayed a high fluorescence quenching ability and different affinity toward single- versus double-stranded DNA. Moreover, the absorption properties of β-Ni(OH) nanosheets can be well controlled by changing cations, solution pH and the length of DNA.