Comparative study on the efficacy and safety of transarterial chemoembolization combined with hepatic arterial infusion chemotherapy for large unresectable hepatocellular carcinoma.

Background: Transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) are two new treatments for hepatocellular carcinoma (HCC). Previous studies had reported that TACE combined with HAIC conferred better survival benefit than TACE alone. The study was to evaluate the availability and safety of TACE combined with HAIC for the treatment of large HCC.

PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.

Small molecule drugs are of significant importance in the treatment of non-small cell lung cancer (NSCLC). Here, we explored biological effects of the PI3K/mTOR inhibitor VS-5584 on NSCLC. Our findings indicated that VS-5584 administration resulted in a dose-dependent inhibition of NSCLC cell proliferation, as well as the induction of apoptosis and cycle arrest.

Study on mechanical properties and damage characteristics of rice straw fiber-reinforced cemented tailings backfill based on energy evolution.

Low-cost and underutilized plant fibers can affect the mechanical behavior of cementitious materials such as cemented tailings backfill (CTB). This paper attempts to explore the mechanical properties and damage evolution characteristics of rice straw fiber (RFS)-reinforced CTB (RSFCTB) from the perspective of energy. A series of mechanical and microscopic tests were carried out on CTB and RSFCTB samples.

Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition.

The purpose of this research is to investigate the effect of tanshinone IIA, an extract of the Chinese medicine Que Xie Hua Yu Tang, on uric acid nephropathy (UAN) and to elucidate the underlying mechanisms. UAN rat model was established. Fifty UAN rats were randomly allocated into 5 groups: adenine-treated group, allopurinol-treated group, and low/middle/high dose of tanshinone IIA-treated groups.

[Clinical study on Dan Shao Tang in treating diabetic nephropathy of deficiency of Yin with damp-heat symptom].

Objective: To explore the effect of Dan Shao Tang (DST) in treating diabetic nephropathy (DN) of deficiency of Yin with damp-heat symptom.

Methods: The 72 patients with DN of deficieny of Yin with damp-heat symptom were randomly divided into two groups. Among them, the 42 patients in treatment group were treated with DST and western medicine and the 30 patients in control group were treated only with western medicine.

[The clinical study on Dan Shao Tang in treating simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom].

Objective: To explore the effect of Dan Shao Tang (DST) in treating simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom.

Methods: Sixty patients of simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom were divided into two groups in random, 35 patients in treatment group were treated with Dan Shao Tang and westen medicine, and 25 patients in control group were treated only with western medicine. The effect, change of hematuria and immunity index of the two groups were observed three months later.

[Clinical observation of "dan shao tang" in treating mesangial proliferative glomerulonephritis of deficiency of yin with damp-heat symptom].

Objective: To explore the effect of "Dan Shao Tang" (DST) on mesangial proliferative glomerulonephritis (MsPGN) of deficiency of Yin with damp-heat symptom.

Methods: 90 patients with MsPGN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 54 patients in treatment group were treated with DST and western medicine, and 36 patients in control group were treated only with western medicine.

[Clinical observation of wenshen xiezhuo decoction in treating pations with chronic renal failure].

Objective: To observe curative effect of Wenshen Xiezhuo Decoction (WSXZD) in treating pations with chronic renal failure (CRF).

Methods: Sixty patients with CRF of deficienncy of spleen-Yang and kidney-Yang with damp pathogen and blood stasis symptom were randomly divided into the treated group and the control group, 30 in each group. Both groups were treated with low-protein diets, controlling hypertension and symptomatic treatment.

[Clinical study on dan shao tang in treating IgA nephropathy of deficiency of yin with damp-heat symptom].

Objective: To explore the effect of Dan Shao Tang(DST) in treating IgA nephropathy(IgAN) of deficiency of Yin with damp-heat symptom.

Methods: 90 patients with IgAN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 50 patients in treatment group were treated with DST and western medicine and 40 patients in control group were treated only with western medicine.

[Clinical observation on colquhounia root tablet in treating lipid metabolism disturbance secondary to nephrotic syndrome].

Objective: To study the effect of Colquhounia root tablet (CRT) in treating nephrotic syndrome with sequential lipid metabolism disorder (NS-LMD).

Methods: The 96 patients with NS-LMD were randomly divided into two groups, the 60 cases in the treated group treated with CRT and the 36 cases in the control group treated with hormone or cytotoxic medicine. The curative effect and the related indexes were determined before and after treatment.

[The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients].

Objective: To explore the correlation of clinical effect and TCRV beta 7 expression of He Jie Decoction (HJD) on chronic hepatitis B patients.

Methods: 45 patients of chronic hepatitis B were divided randomly into two groups. 30 patients in the treated group were treated by HJD, and 15 patients in the control group were treated by usual western medicine.

[Clinical study of treatment on chronic uric acid nephropathy by integrating Western and traditional Chinese medicine].

Objective: To investigate the ameliorative effect on chronic uric acid nephropathy (CUAN) by integrating western and traditional Chinese medicine (IWTCM).

Methods: The 136 CUAN patients were divided into two groups at random, the therapy group of 86 patients were treated by Chinese medicine and allopurinol, and the control group of 50 patients were treated only by allopurinol. The curative effect and the related index such as blood uric acid, renal function, urinary protein, microproteins, blood lipid and hyperviscosity were determined before and after being treated.