FHOD3 shows clinical significance in progression of ovarian cancer through regulation of caspase-3 signaling pathway.

Ovarian cancer is a malignant disease threatening women's life. Traditional therapies bring little benefits for the patients with distant metastasis or recurrence. FHOD3 gene was reported to promote progression in cancer.

A Study on the Identification of High-Risk Factors and the Establishment of a Prediction Model for Uterine Rupture in an Unscarred Uterus During Pregnancy.

Objective: The diagnosis of uterine rupture was often delayed or misdiagnosed, leading to maternal morbidity and fetal mortality. The current study was performed to retrospectively identify high-risk factors of uterine rupture in an unscarred uterus (USU), and to establish a model to predict uterine rupture in USU during pregnancy.

Methods: This was a retrospective multi-center study including five regional medical centers from the inception of each medical center to December 31 2021.

Second curettage versus conventional chemotherapy in avoiding unnecessary chemotherapy and reducing the number of chemotherapy courses for patients with gestational trophoblastic neoplasia: A systematic review and meta-analysis.

Background: Chemotherapy is the recommended treatment for gestational trophoblastic neoplasia (GTN). Second curettage had been advocated to avoid unnecessary chemotherapy and to reduce the courses of chemotherapy; however, consensus has not been reached as there are arguments claiming its inability of inducing complete regression.

Objectives: The present study was performed to clarify the effectiveness of second curettage for avoiding unnecessary chemotherapy and lowering the number of chemotherapy courses in patients with post-molar GTN.

Risk factors for adverse pregnancy outcomes in Chinese women: a meta-analysis.

Objective: This study examined the associated risk factors of adverse pregnancy outcomes among Chinese females and furnished some fundamental principles and recommendations for enhanced prevention of adverse pregnancy and preservation of women's well-being.

Methods: A systematic review was conducted by retrieving the MEDLINE (The National Library of Medicine), Embase, PubMed, and Cochrane databases. The relevant risk factors for adverse pregnancy in Chinese women were retrieved from May 2017 to April 2023.

Clinical characteristics of uterine rupture without previous Cesarean section: A 25-year retrospective study.

Aim: To investigate the clinical characteristics and risk factors of uterine rupture without preceding Cesarean section.

Methods: The medical records of all deliveries at the Women's Hospital, Zhejiang University School of Medicine between 1992 and 2017 were reviewed. All cases of uterine rupture without previous Cesarean delivery were included.

Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis.

Objective: This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women.

Methods: Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/exclusion criterion, 14, 8, 10, and 9 studies were chosen for testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin, respectively, for this meta-analysis.