Publications by authors named "JunYan Zhang"
Introduction: This study was designed to describe the profile of co-occurring or secondary infections in hospitalized coronavirus disease 2019 (COVID-19) patients undergoing hyperbaric oxygen therapy (HBOT) and those without.
Methodology: Out of 716 COVID-19 patients, 79 cases of co-occurring or secondary infections were included. These patients were categorized into two groups based on their usage of HBOT.
Purpose: To investigate the outcomes and risk factors for patients with hematologic malignancies (HM) following late-stage SARS-CoV-2 infection.
Background: Patients with HM such as lymphoproliferative malignancies (including acute lymphoblastic leukemia and multiple myeloma) and myeloproliferative malignancies (including acute myeloid leukemia, myeloproliferative neoplasm, and myelodysplastic syndrome) are at increased risk of severe illness and high mortality from COVID-19. This study examines the impact of SARS-CoV-2 infection severity on HM prognosis during the late phase of COVID-19, using data from 203 patients at Shanxi Bethune Hospital.
Allergic rhinitis (AR) is a global disease with high prevalence. It reduces the patient's quality of life seriously. The health care and management of AR was also a heavy social burden.
View Article and Find Full Text PDFBackground: Plant-based diets have been found to be associated with hypertension. Dietary intake is a dynamic and changing process that can be better characterized by trajectories of dietary indices. However, the associations between plant-based diet trajectories and hypertension over time remained unknown.
View Article and Find Full Text PDFEffect of Hyperbaric Oxygen Therapy on Patients with SARS-CoV-2 Infection: A Retrospective Cohort Study.
J Multidiscip Healthc
November 2024
Objective: The aim of this study was to evaluate the impact of hyperbaric oxygen therapy (HBOT) on patients with SARS-CoV-2 infection and determine its efficacy and safety in reducing treatment failure events.
Methods: A retrospective cohort study involving patients with COVID-19 was conducted. Inverse probability of treatment weighting (IPTW) was used to balance covariates between the HBOT and non-HBOT groups.
Neurodegenerative diseases (NDDs), as a neurological disorder characterised by neuronal degeneration and death, are a serious threat to human health and have long attracted attention due to their complex pathogenesis and the ineffectiveness of therapeutic drugs. Existing studies have shown that Polygonatum Sibiricum polysaccharides (PSP) have immunoregulatory, antioxidant, anti-inflammatory and other pharmacological effects, and their neuroprotective effects have been demonstrated in several scientific studies. This paper reviews the main pharmacological effects and mechanisms of PSP in the protection and treatment of NDDs, to provide a reference for the clinical application and basic research of PSP in NDDs.
View Article and Find Full Text PDFIncreasing lifespans and external environmental factors have contributed to the increase of age-related diseases, particularly cancer. A decrease in immune surveillance and clearance of cancer cells is the result of immunosenescence, which involves the remodeling of immune organs, the changes and functional decline of immune cell subsets, in association with systemic low-grade chronic inflammation. Stem cells aging in bone marrow and thymic involution are the most important causes of immunosenescence.
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- - Aerogels are great for thermal clothing but face challenges with mechanical fragility and structural instability, which can limit their use.
- - Researchers have found a solution by creating industrial-scale sea-island melt-spun ultrafine fibers that are assembled into durable aerogel felts using freeze-shaping technology.
- - These new aerogels are not only strong and flexible but also self-cleaning, waterproof, and provide excellent thermal insulation, making them ideal for extreme environments and a viable alternative to traditional insulating clothing like down jackets.
Despite its unrivaled hardness, polycrystalline diamond can be severely worn under the interaction with softer copper during the ultrafine copper wire drawing process. The influence of the polycrystalline diamond surface state on its friction behavior is investigated in this work, and argon, oxygen, and hydrogen plasma treatments are adopted to regulate the surface state of diamond. When sliding against copper, the original diamond plate exhibits a coefficient of friction (COF) exceeding 0.
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- Ticagrelor is a new and effective P2Y12 inhibitor used in managing patients with STEMI, showing advantages over the traditional drug clopidogrel in preventing blood clots after treatment.
- *Key clinical trials, including TREAT and MIRTOS, demonstrate ticagrelor's superior ability to inhibit platelets without significantly increasing bleeding risks, suggesting it's a promising option.
- *Despite its potential benefits, clopidogrel is still the recommended treatment, so more research is needed to better understand ticagrelor's long-term impacts and best usage in cardiovascular care.*
Article Synopsis
- * This study introduces a method to improve the stability of these catalysts by anchoring nickel sites within dealuminated Beta zeolite, which enhances metal-support interactions.
- * Using advanced techniques like X-ray absorption spectroscopy and isotopic experiments, the research explains how the synthesis method increases the performance and durability of the Ni catalysts by reducing unwanted byproducts.
Article Synopsis
- - The study investigated stress levels among nurses, identifying three distinct categories: low, moderate, and high perceived stress, with most nurses (66.7%) falling into the moderate category.
- - Data were collected from 696 nurses in Shanxi Province, China, through electronic surveys that measured factors like sociodemographics, job stressors, effort-reward imbalance, and organizational support.
- - Key findings highlighted that working hours and effort-reward imbalance significantly influenced stress levels, showing that longer hours and higher extrinsic effort correlated with increased perceived stress among nurses.
Background: Optical coherence tomography (OCT) has gained increasing popularity in coronary artery intervention due to its high resolution and excellent tissue correlation as a novel intravascular imaging modality. However, the current use of OCT requires contrast agent injection for imaging, and excessive use of contrast agents may adversely affect renal function, exacerbate cardiac burden, and even lead to contrast agent-induced nephropathy and heart failure. In recent years, several researchers have proposed the use of low molecular weight dextran (LMWD) as a substitute for contrast agents in OCT imaging because of its low toxicity, low cost, and wide availability.
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- The study investigates transfusion thresholds in patients with coronary artery disease undergoing hip surgery, comparing restrictive (8 g/dL hemoglobin) and liberal (10 g/dL hemoglobin) transfusion strategies.
- A total of 805 patients were analyzed, with primary outcomes focusing on severe events like in-hospital death and heart complications.
- Results showed no significant difference in overall primary outcomes between the two groups, but the liberal transfusion group experienced fewer in-hospital myocardial infarctions, suggesting potential benefits of a more liberal approach.
Article Synopsis
- Post-stroke depression (PSD) is common and can negatively impact recovery; the study explores a new treatment approach combining acupuncture and music therapy.
- A meta-analysis of 11 randomized controlled trials with 698 patients showed significant improvements in depression levels and sleep quality for those receiving the treatment compared to a control group.
- The findings suggest that this combined therapy is effective in alleviating symptoms of depression in patients suffering from PSD.
This study was intended to investigate the macular vascular and photoreceptor changes for diabetic macular edema (DME) at the early stage. A total of 255 eyes of 134 diabetes mellitus patients were enrolled and underwent an ophthalmological and systemic evaluation in this cross-sectional study. Early DME was characterized by central subfoveal thickness (CST) value between 250 and 325 μm, intact ellipsoid zone, and an external limiting membrane.
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- The study investigates the mental health issues, specifically anxiety and depression, faced by people living with HIV (PLWH) and how these issues are evaluated by both patients and physicians.
- A total of 5,000 PLWH and 500 physicians participated in a cross-sectional study, revealing that the agreement (concordance) between how physicians and PLWH perceive depressive and anxiety issues is significantly lower than expected (around 73.84% for depression and 71.74% for anxiety).
- Results indicate that physicians tend to overestimate depressive and anxiety issues compared to patients, with mismatch rates of 26.16% for depression and 28.26% for anxiety, highlighting the need for improved communication and assessment methods in
Article Synopsis
- Percutaneous coronary intervention is a key treatment for coronary artery disease, especially for heart attacks, but traditional metallic stents can cause complications that bioresorbable stents aim to mitigate.
- Bioresorbable polymeric stents face challenges like low mechanical strength, leading to thrombosis and inflammation, which has prompted interest in using bioresorbable metals like iron, zinc, and magnesium instead.
- Early studies show promise for zinc and magnesium stents in terms of safety and absorption rates, but more extensive human clinical trials are necessary to confirm their effectiveness and address current limitations.
Article Synopsis
- Percutaneous coronary intervention (PCI) is a common treatment for coronary artery disease, but a distinct group of high-risk patients poses challenges due to increased chances of both ischemia and bleeding.
- Currently, there is no clear definition or standard treatment for this high-risk population, although genotype-guided antithrombotic therapy has been proposed for more personalized care.
- Recent studies indicate that routine genetic testing does not improve outcomes for PCI patients, leading to the recommendation of a short course of dual antiplatelet therapy followed by monotherapy, while more research is needed to determine the best treatment strategies for these patients.
Article Synopsis
- PVC, a common material, is not recycled due to its degradation into toxic byproducts at high temperatures, prompting the need for a controlled dechlorination process.
- Researchers have developed a method to dechlorinate PVC at a mild temperature of 200°C using a liquid metal catalyst (Ga), achieving about a 90% reduction in chlorine content while minimizing harmful gas production.
- The Ga catalyst enhances contact with PVC, allows chlorine to be easily removed afterward, can be reused, and effectively processes discarded PVC materials more efficiently than traditional catalysts.
To examine the prevalence of comorbidities in Chinese urticaria patients and assess medication use patterns across different ages (6-11 years, 12-17 years, above 18 years), a retrospective cohort study was performed in 192,647 urticaria patients within the Health Database. After 1:1 propensity score matching, 166,921 people were divided into the urticaria group and the control group, and the follow-up data were collected within 2 years. During the 12-month and 24-month follow-up period, significant comorbidities identified included allergic rhinitis and asthma, with distinct patterns observed across age groups.
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- Global population growth and industrialization have heightened the demand for environmentally friendly materials, particularly biomass-based aerogels (BAs), known for their biocompatibility, degradability, and renewability.
- The review emphasizes the importance of micro-structural design in enhancing the functionality of BAs, demonstrating that different microstructures can lead to varied properties and applications despite similar biomolecular compositions.
- It covers the preparation processes, design concepts, and potential uses of BAs in fields like thermal management, water treatment, energy storage, and EMI shielding, while also discussing future challenges and opportunities in the research of these materials.
Article Synopsis
- Flexible light-emitting fibers and fabrics enhance human-machine interactions and are seeing rapid structural advancements for practical use and commercialization.
- The review details the design principles and evolution of coaxial light-emitting fibers, as well as innovative helical structures that improve their mechanical sensitivity.
- It also covers continuous manufacturing techniques for large-area smart fabrics and highlights challenges and future prospects in wearable and smart technology applications.