Kidney transcriptome analysis reveals the molecular responses to salinity adaptation in largemouth bass (Micropterus salmoides).

Recently, against the background of increasing land salinization and global warming, many studies have examined the mechanisms of freshwater fish adaptation to elevated salinity. However, the mechanisms underlying salinity tolerance in the kidney of Micropterus salmoides, a popular saline aquaculture species, remain poorly understood. We used RNA-seq to explore the differentially expressed genes (DEGs) in the kidney of M.

Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter.

Background: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with substantial morbidity and mortality. Oxidative stress (OS) has been implicated in the pathogenesis of AF, suggesting that targeting OS-related genes could offer novel therapeutic opportunities. This study aimed to identify causal OS-related genes contributing to AF through a comprehensive multi-omics Summary-based Mendelian Randomization (SMR) approach.

Transcriptome analysis reveals candidate miRNAs involved in skin color differentiation of juvenile Plectropomus leopardus in response to different background colors.

Red skin color in Plectropomus leopardus is important to its ornamental and economic value. However, the color of P. leopardus can change during the rearing process, darkening and turning black due to the influence of environmental background color.

The muscle nutritional components analysis of golden pompano () in different mariculture area, growth stages, and genders.

Golden pompano () is an economically important fish which exhibits sexual size dimorphism and is widely cultivated in the southern seas of China. To evaluate the nutritional composition of of different mariculture areas, growth stages, and genders, the moisture, ash, amino acids, and fatty acids in the muscle were measured using national standard biochemical assay. The analysis found 16 kinds of amino acids in the muscle of .

A protocol for gradient coating design zinc anodes for stable zinc ion batteries.

In this protocol, we present a modified gradient coating strategy for zinc anodes. We describe steps for synthesizing electrodes, measuring electrochemistry, and assembling and testing batteries. The protocol can be applied for broadening design ideas of functional interface coating.

Reactive oxygen species-mediated phosphorylation of JNK is involved in the regulation of BmFerHCH on Bombyx mori nucleopolyhedrovirus proliferation.

c-Jun N-terminal kinase (JNK) phosphorylation is widely observed during virus infection, modulating various aspects of the virus-host interaction. In our previous research, we have proved that B. mori ferritin heavy-chain homolog (BmFerHCH), an inhibitor of reactive oxygen species (ROS), facilitates B.

Transcriptome analysis of differentially expressed circular RNAs in the testis and ovary of golden pompano (Trachinotus blochii).

The artificial breeding of golden pompano (Trachinotus blochii) has expanded greatly in recent years, and after long-term breeding efforts, clear sexual dimorphisms have been observed in T. blochii growth traits, with females growing faster. As sponges of microRNA (miRNAs), circular RNAs (CircRNAs) can alleviate miRNA inhibition of target mRNA.

The Effect of Background Color on Skin Color Variation of Juvenile .

Fish skin color is usually strongly affected by the background color of their environment. The study investigated the effects of five different background colors on the skin color of leopard coral groupers (Plectropomus leopardus). More than 450 juveniles were reared in Blue, Red, Black, White, and Transparent background tanks for 56 days.

Transcriptome Analysis Reveals the Complex Regulatory Pathway of Background Color in Juvenile Skin Color Variation.

Fish skin color is often strongly affected by background color. We hypothesized that the regulatory mechanism of variations in skin color in is linked to the background color. In this study, we conducted transcriptome analysis of cultured under different background colors to compare gene expression levels and the important signaling pathways.

Mesoporous vanadium nitride as anion storage electrode for reverse dual-ion hybrid supercapacitor.

In traditional dual-ion systems, the cathode usually is employed as anion-storage materials. Herein, we propose a new dual-ion hybrid supercapacitor with reverse anion/cation-storage mechanism, consisting of a mesoporous (MPs) VN anode as a pivotal anion-storage material and KMnO nanosheet arrays grown on carbon cloth (NSs/CC) as (K-storage) cathode. During charge/discharge, the anode and cathode reversibly store/release OH ions and K ions, respectively.

Multifunctional integrated VN/VO heterostructure sulfur hosts for advanced lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries show great potential in future electric transportation and large-scale grid storage applications because of their attractive theoretical energy density (2600 W h kg) and relatively abundant sulfur reserves. However, the rapid capacity decay and unsatisfactory sulfur loading caused by the lithium polysulphide (LiPS) dissolution and low electrical conductivity of sulfur are the most urgent issues plaguing its practical applications. Herein, we report a multifunctional nanoporous (NP) VN/VO binary host that can efficiently resolve the above conflicts by the synergy between the functions of two materials.

A new potassium dual-ion hybrid supercapacitor based on battery-type Ni(OH) nanotube arrays and pseudocapacitor-type VO-anchored carbon nanotubes electrodes.

Hybrid supercapacitors (HSCs) with the characteristics of high energy density, long cycle life and without altering their power density need to be developed urgently. Herein, a novel dual-ion hybrid supercapacitors (DHSCs) with Ni(OH) nanotube arrays (NTAs) as positive electrode and VO directly grown on freestanding carbon nanotubes (CNTs) as negative electrode is assembled. In charging mechanism of DHSCs, K are inserted into the VO negative while OH react with Ni(OH) positive; during discharge, the K and OH are released from VO negative and Ni(OH) positive, respectively, and return back to the electrolyte, which is quite different from traditional metal ion or alkaline supercapacitors.

EZH2 is a potential prognostic predictor of glioma.

The enhancer of zeste homologue 2 (EZH2) is a histone H3 lysine 27 methyltransferase that promotes tumorigenesis in a variety of human malignancies by altering the expression of tumour suppressor genes. To evaluate the prognostic value of EZH2 in glioma, we analysed gene expression data and corresponding clinicopathological information from the Chinese Glioma Genome Atlas, the Cancer Genome Atlas and GTEx. Increased expression of EZH2 was significantly associated with clinicopathologic characteristics and overall survival as evaluated by univariate and multivariate Cox regression.

Co-modulation of Liver Genes and Intestinal Microbiome of Largemouth Bass Larvae () During Weaning.

In recent years, largemouth bass have become one of the most commonly aquacultured species in China, however, its low survival rate during larval weaning has always been a bottleneck that has restricted industrial development. Understanding the changes in liver metabolism and intestinal microflora during the weaning of largemouth bass larvae can help to design better weaning strategies and improve survival. In this study, liver mRNA and intestinal microflora 16S rRNA genes were analyzed using high-throughput sequencing at the pre, mid, and post weaning stages [15, 30, 45 days post hatching; total length (cm) were 2.

Combined exposure to hypoxia and ammonia aggravated biological effects on glucose metabolism, oxidative stress, inflammation and apoptosis in largemouth bass (Micropterus salmoides).

Hypoxia and ammonia are unavoidable environmental factors in aquaculture, and have been shown cause various adverse effects in fish. In the present study, a two-factor crossover experiment was carried out to evaluate the combined effect of hypoxia and ammonia on oxidative stress and glucose metabolism endpoints in largemouth bass. The fish were divided into four experimental groups: hypoxia and ammonia group, hypoxia group, ammonia group, and control group.

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas.

The aim of the present study was to explore the expression profiles of lncRNAs and mRNAs in glioma patients and to elucidate any potential relationship between lncRNAs and mRNAs in glioma. High-throughput transcriptome sequencing of mRNAs and lncRNAs from six normal tissues and 16 glioma tissues (grade II, six cases; grade III, four cases; and grade IV, six cases) was performed. Series test of cluster (STC) analysis was used to screen significant trending models associated with glioma.

Interactive effect of thermal and hypoxia on largemouth bass (Micropterus salmoides) gill and liver: Aggravation of oxidative stress, inhibition of immunity and promotion of cell apoptosis.

High temperatures and low oxygen in aquatic environments, such as intensive aquaculture or in natural watersheds, inevitably cause stress in fish. Fish are exposed to high temperatures during the summer, which exacerbates hypoxia. Hypoxia (1.

Potential regulation by miRNAs on glucose metabolism in liver of common carp (Cyprinus carpio) at different temperatures.

Water temperature can affect the metabolism of fish. Common carp (Cyprinus carpio) is a representative eurythermic fish that can survive at a wide range of ambient temperatures, allowing it to live in an extensive geographical range. The goal of this work was to study the glucose metabolism of common carp at different temperatures and determine the miRNAs involved in the regulation of glucose metabolism.