Publications by authors named "JunJun Wu"

The Qilian Mountain Area (QMA) serves as a crucial ecological barrier and strategic water conservation zone in China. Recent years have seen heightened social attention to environmental issues within the QMA, underscoring the need for accurate and continuous land cover maps to support ecological monitoring, analysis, and forecasting. This paper presents the QMA_LC30 dataset, which includes 9 land cover categories and spans the period from 1990 to 2020, with updates every 5 years.

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Cell death is a central process for organismal health. Pyroptosis, namely pyroptotic cell death, is recognized as a critical type that disrupts membrane and triggers pro-inflammatory cytokine secretion gasdermins, providing a robust form of cytolysis. Meanwhile, along with the thorough research, a great deal of evidence has demonstrated the dual effects of pyroptosis in host defense and inflammatory diseases.

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Article Synopsis
  • * An 84-year-old male with acute liver failure from hepatitis E developed worsening symptoms and was diagnosed with an invasive fungal infection caused by Aspergillus fumigatus, confirmed by advanced diagnostic techniques.
  • * The case emphasizes the critical need for close monitoring and early intervention in elderly liver failure patients, as prognosis can be poor despite aggressive treatment efforts.
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Municipal solid waste incineration (MSWI) fly ash, classified as a hazardous waste due to its high toxicity, poses a significant environmental challenge that existing treatment methods struggle to manage effectively. Although high-temperature thermal treatment has proven effective in handling hazardous waste, its large-scale industrial adoption is hindered by the associated high costs and energy demands. A promising alternative is the conversion of MSWI fly ash into high-value glass-ceramic materials, which presents both environmental and economic benefits.

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  • Esketamine is the first fast-acting antidepressant approved by the FDA but has limited use due to addiction risks; SAL0114 is a new formulation aiming to improve safety and efficacy by combining deuterated dextromethorphan with bupropion.
  • Research methods included binding assays to evaluate the effects of deuteration, stability tests in mice, and various animal models to assess antidepressant effects.
  • Results showed that deuterated dextromethorphan had double the metabolic stability of regular dextromethorphan and worked synergistically with bupropion, leading to superior effectiveness in treating depression.
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The enzymatic depolymerization is a promising route to valorize the lignin polymers by turning the cross-linked polymers into monomers or oligomers. However, the lignin polymers cannot be effectively converted into small chemicals, as the oligomers are prone to polymerization, which is particularly challenging to monitor and thus regulate. Here, we develop a microstructured fiber Bragg grating (mFBG) sensor to probe the dynamic polymerization process of typical lignin oligomer surrogates─guaiacol (monomer) and guaiacylglycerol-β-guaiacyl ether (GBG, dimer)─catalyzed by laccase in an way.

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Our previous study has shown that exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs-exo) alleviated burn-induced acute lung injury (ALI). In this study, we explored a novel mechanism by which hUCMSCs-exo contributed to the inhibition of burn-induced ALI. The ALI rat model with severe burn was established for the in vivo experiments, and rats PMVECs were stimulated with the serum from burn-induced ALI rats for the in vitro experiments.

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Background: Acute liver injury (ALI) is a serious syndrome with a high mortality rate due to viral infection, toxic exposure, and autoimmunity, and its severity can range from mildly elevated liver enzymes to severe liver failure. Activation of the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is closely associated with the development of ALI, and the search for an inhibitor targeting this pathway may be a novel therapeutic option. Anoectochilus roxburghii polysaccharide (ARP) is a biologically active ingredient extracted from Anoectochilus roxburghii with immunomodulatory, antioxidant, and anti-inflammatory bioactivities and pharmacological effects.

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Photoelectrochemical (PEC) water splitting is gaining recognition as an effective method for producing green hydrogen. However, the absence of in situ, continuous decoding hydrogen generation tools hampers a detailed understanding of the physics and chemistry involved in hydrogen generation within PEC systems. In this article, we present a quantitative, spatiotemporally resolved optical sensor employing a fiber Bragg grating (FBG) to probe hydrogen formation and temperature characteristics in the PEC system.

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The interfacial correlation factor (), where refers to the interaction among ice, water and the substrate and refers to the ratio of the critical nucleation size to the surface topography characteristic size of the substrate, plays a crucial role in the classical theory of heterogeneous ice nucleation as it significantly impacts the energy of nucleation. Generally, a smaller value of () indicates a higher propensity for ice nucleation. The degree of structural compatibility between ice and the substrate greatly influences (), particularly on specific substrates.

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Riparian zones, regarded as hotspots for greenhouse gas (GHG) emissions, where the variation in temperature sensitivity (Q) of GHG emissions is crucial for assessing GHG budgets under global warming. However, the seasonal Q of GHG emissions from high-elevation riparian zones and underlying microbial mechanisms are poorly documented. This study focuses on seasonal Q patterns of GHG emissions from riparian zones along the Lhasa River on the Tibetan Plateau.

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A growing demand for sustainable, alternative protein sources that are nutrient-dense, such as microorganisms, and insects, has gradually evolved. When paired with effective processing techniques, yeast cells contain substantial substances that could supply the population's needs for food, medicine, and fuel. This review article explores the potential of yeast proteins as a sustainable and viable alternative to animal and plant-based protein sources.

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Yarrowia lipolytica is widely used in biotechnology to produce recombinant proteins, food ingredients and diverse natural products. However, unstable expression of plasmids, difficult and time-consuming integration of single and low-copy-number plasmids hampers the construction of efficient production pathways and application to industrial production. Here, by exploiting sequence diversity in the long terminal repeats (LTRs) of retrotransposons and ribosomal DNA (rDNA) sequences, a set of vectors and methods that can recycle multiple and high-copy-number plasmids was developed that can achieve stable integration of long-pathway genes in Y.

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Droplet directional transport is one of the central topics in microfluidics and lab-on-a-chip applications. Selective transport of diverse droplets, particularly in another liquid phase environment with controlled directions, is still challenging. In this work, we propose an electric-field gradient-driven droplet directional transport platform facilitated by a robust lubricant surface.

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Background: Children with acute lymphoblastic leukaemia (ALL) experience multiple symptoms that occur in complicated patterns and negatively affect patient outcomes. To date, no systematic review has been performed on the prevalence of symptoms in children with ALL.

Objective: The study aimed to report and analyse the prevalence of symptoms in children with ALL during treatment.

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Reversed-electrowetting based droplet electricity generator (REWOD-DEG) shows merits in high power densities, tunable output formats, and wide adaptability to diverse mechanical energies. However, the surface charge trapping and dielectric failure, which are also common challenges for electrowetting system, hinders the development of reliable REWOD-DEGs for long-term running. We innovatively introduce a slippery lubricant-infused porous surface (SLIPS) into REWOD-DEG.

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Self-assembling peptides are valuable building blocks to fabricate supramolecular biomaterials, which have broad applications from biomedicine to biotechnology. However, limited choices to induce different globular proteins into hydrogels hinder these designs. Here, an easy-to-implement and tunable self-assembling strategy, which employs Ure2 amyloidogenic peptide, are described to induce any target proteins to assemble into supramolecular hydrogels alone or in combination with notable compositional control.

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Grasslands represent the largest ecosystem in China, accurate and efficient extraction of its integrated vegetation cover (IVC) plays a crucial role in supporting policy decisions. This study presented a method for grassland monitoring via IVC derived from high-resolution satellite data. Taking the multispectral data of Gaofen-1 (GF-1) and Gaofen-6 (GF-6) with 16 m resolution as the main data source, vegetation cover of six representative regions was assessed based on mixed-pixel decomposition model.

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The waste-to-energy and manganese industries face significant ecological challenges due to two major risk sources: municipal solid waste incineration (MSWI) fly ash and electrolytic manganese residue (EMR), especially, the MSWI fly is classified as hazardous waste. High temperature melting is a promising method for harmless disposal of solid wastes. However, it has yet to be industrialized due to the high costs and energy consumption.

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The assessment of land cover and changes will help to understand the temporal and spatial pattern of land cover in the world and the Belt and Road (B&R) region, and provide reference information for global sustainable development and the Belt and Road construction. In this paper, the 1 km global land cover classification maps of 2016 and 2020 with a high accuracy of 88% are mapped using the Moderate Resolution Imaging Spectroradiometer (MODIS) time series surface reflectance products. Based on the maps, the land cover status of the world and the Belt and Road region, the land cover change from 2016 to 2020, and the mutual transformation characteristics between various types, are analyzed.

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Purpose: To investigate the level of fear of cancer recurrence (FCR) in spouses of patients with lymphoma and its relationship with patients' FCR, as well as the correlations between FCR, sense of spousal support (SSS), anxiety, and depression in the couples.

Methods: A cross-sectional study of 233 couples where one partner had lymphoma was conducted from May 2021 to February 2022. Participants provided demographic information and completed the Spouse Support Inventory and Hospital Anxiety and Depression Scale.

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Background: Escherichia coli can cause severe infections. The latter can lead to disseminated intravascular coagulation (DIC). The importance of an early diagnosis of DIC is illustrated through this case report.

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Lipids are a large group of essential nutrients in daily diets that provide energy and maintain various physiological functions. As the global population is rapidly expanding, there is an urgent need to enhance the production and quality of food lipids. The development of modern biotechnology allows the manipulation of oil production in plants and microorganisms and the improvement of the nutritional value of food lipids.

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Purpose: This study aimed to explore the positive experiences of dyadic coping between patients with acute leukemia and their spouses in China, and to highlight the target factors that could promote coping and adaptation.

Methods: A qualitative descriptive study was employed. This study was conducted at a tertiary hospital in China from September 2021 to February 2022.

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