STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC.

Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial-to-mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in the development of mesenchymal and immune evasion phenotypes in KIRC cells.

Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC.

High invasive capacity and acquired tyrosine kinase inhibitors (TKI) resistance of kidney renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of patients with advanced KIRC. In the present study, we reported that sine oculis homeobox 1 (SIX1) was upregulated in sunitinib-resistant KIRC cells and metastatic KIRC tissues. Subsequently, we found that SIX1 mediated metastasis and sunitinib resistance via Focal adhesion (FA) signaling, and knockdown of SIX1 enhanced the antitumor efficiency of sunitinib in KIRC.

Unveiling the bifunctional roles of Cetyltrimethylammonium bromide in construction of NbCT@MoSe heterojunction for fast potassium storage.

Exploring robust electrode materials which could permit fast and reversible insertion/extraction of large K is a crucial challenge for potassium-ion batteries (PIBs). Smart interfacial design could facilitate electron/ion transport as well as assure the integrity of electrode. Herein, Cetyltrimethylammonium bromide (CTAB) was found to play bifunctional roles in construction of NbCT@MoSe heterostructure.

Appearance quality, nutritional value, and aroma components of wild diguo ( Bur.) fruit collected from southwest China.

Diguo ( Bur.), an ancient wild fruit, is widely spread in southwest China. However, there is little information on the phenotypic traits, quality characteristics, and aroma compounds available to diguo fruit.

Modeling Tree-like Heterophily on Symmetric Matrix Manifolds.

Tree-like structures, characterized by hierarchical relationships and power-law distributions, are prevalent in a multitude of real-world networks, ranging from social networks to citation networks and protein-protein interaction networks. Recently, there has been significant interest in utilizing hyperbolic space to model these structures, owing to its capability to represent them with diminished distortions compared to flat Euclidean space. However, real-world networks often display a blend of flat, tree-like, and circular substructures, resulting in heterophily.

Edge-oriented growth of cadmium sulfide nanoparticles on nickel metal-organic framework nanosheets for photocatalytic hydrogen evolution.

In this study, a directional loading of cadmium sulfide (CdS) nanoparticles (NPs) was achieved on the opposite edges of nickel metal-organic framework (Ni-MOF) nanosheets (NSs) by adjusting the weight ratio of CdS NPs in the reaction process to produce effective visible light photocatalysts. The close contact between the zero-dimensional (0D) and two-dimensional (2D) regions and the matching positions of the bands promoted charge separation and heterojunction formation. The optimal CdS NPs loading of composite material was 40 wt%.

GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling.

Growth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients.

Elastic MXene conductive layers and electrolyte engineering enable robust potassium storage.

The precisely engineered structures of materials greatly influence the manifestation of their properties. For example, in the process of alkali metal ion storage, a carefully designed structure capable of accommodating inserted and extracted ions will improve the stability of material cycling. The present study explores the uniform distribution of self-grown carbon nanotubes to provide structural support for the conductive and elastic MXene layers of TiCT-Co@NCNTs.

Architecting carbon-coated MoCT/MoSe heterostructures enables robust potassium storage.

Herein, carbon-coated MoSe decorated MoCT MXene heterostructures (MoSe/MoCT@C) have been fabricated. MoCT works as a dual-function electron/ion conductor, which not only provides high conductivity and mechanical strength, but also prevents the severe self-aggregation of few layered MoSe nanosheets. The high reversible capacities of 405 mA h g at 100 mA g after 150 cycles and 258 mA h g at 2000 mA g after 400 cycles could be achieved for a potassium-ion battery.

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer.

Objectives: DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.

Methods: The inhibition of DOT1L was used by SGC0946 and short hairpin RNA silencing.

Solvent- and Co-Catalyst-Free Cycloaddition of Carbon Dioxide and Epoxides Catalyzed by Recyclable Bifunctional Niobium Complexes.

CO, as a cheap and abundant renewable C1 resource, can be used to synthesize high value-added chemicals. In this paper, a series of bifunctional metallic niobium complexes were synthesized and their structures were characterized by IR, NMR and elemental analysis. All of these complexes have been proved to be efficient catalysts for the coupling reaction of CO and epoxides to obtain cyclic carbonates under solvent- and co-catalyst-free conditions.

Construction of Hollow CoO@ZnInS p-n Heterojunctions for Highly Efficient Photocatalytic Hydrogen Production.

Photocatalysts derived from semiconductor heterojunctions for water splitting have bright prospects in solar energy conversion. Here, a CoO@ZIS p-n heterojunction was successfully created by developing two-dimensional ZnInS on ZIF-67-derived hollow CoO nanocages, realizing efficient spatial separation of the electron-hole pair. Moreover, the black hollow structure of CoO considerably increases the range of light absorption and the light utilization efficiency of the heterojunction avoids the agglomeration of ZnInS nanosheets and further improves the hydrogen generation rate of the material.

Solvent-Free Coupling Reaction of Carbon Dioxide and Epoxides Catalyzed by Quaternary Ammonium Functionalized Schiff Base Metal Complexes under Mild Conditions.

A series of bifunctional Schiff base metal catalysts (Zn-NPClR, Zn-NPXH, and M-NPClH) with two quaternary ammonium groups were prepared for carbon dioxide (CO) and epoxide coupling reactions. The effects of the reaction variables on the catalytic activity were systematically investigated, and the optimal reaction conditions (120 °C, 1 MPa CO, 3 h) were screened. The performances of different metal-centered catalysts were evaluated, and Co-NPClH showed excellent activity.

α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila.

Posttranslational modification of tubulin increases the dynamic complexity and functional diversity of microtubules. Acetylation of α-tubulin at Lys-40 is a highly conserved posttranslational modification that has been shown to improve the flexibility and resilience of microtubules. Here we studied the in vivo functions of α-tubulin acetylation by knocking-out Atat, the Drosophila α-tubulin acetyltransferase, and by mutating Lys-40 to Arg in α1-tubulin.

DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma.

DOT1L, the only histone H3 lysine 79 methyltransferase, has a prominent effect on promoting the progression of various malignancies, yet the functional contribution of DOT1L to renal cell carcinoma (RCC) progression remains unclear. DOT1L is overexpressed in RCC and linked to poor clinical outcomes. Chemical (SGC0946) or genetic suppression of DOT1L attenuates the growth and invasion of renal cancer cells and results in S-phase arrest.

Functionalized β-Cyclodextrins Catalyzed Environment-Friendly Cycloaddition of Carbon Dioxide and Epoxides.

Ammonium, imidazole, or pyridinium functionalized β-cyclodextrins (β-CDs) were used as efficient one-component bifunctional catalysts for the coupling reaction of carbon dioxide (CO) and epoxide without the addition of solvent and metal. The influence of different catalysts and reaction parameters on the catalytic performance were examined in detail. Under optimal conditions, Im-CD1-I catalysts functionalized with imidazole groups were able to convert various epoxides into target products with high selectivity and good conversion rates.

The role of histone methylation in renal cell cancer: an update.

Renal cell carcinoma accounts for 2-3% of all cancers. It is difficult to diagnose early. Recently, genome-wide studies have identified that histone methylation was one of the functional classes that is most frequently dysregulated in renal cell cancer.

Anion substitution induced vacancy regulating of cobalt sulfoselenide toward electrocatalytic overall water splitting.

Anion substitution is a valid strategy to modulate the active sites of the transition metal dichalcogenides (TMDs). Herein, a series of cobalt sulfoselenide nanomeshes (CoSSe@NC) were synthesized by calcining S/Se power with ultrathin metal-organic framework (MOFs) nanosheets. The vacancy concentration of CoSSe@NC could be adjusted through changing the ratio of S/Se precursor.

Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer.

Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis is considered an emerging target for tumor therapy. However, the role of ferroptosis in energy stress in renal cancer is currently unknown.

Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinoma.

Background: Nuclear receptor subfamily 1 group H member 4 (NR1H4) have been reported in various cancer types, however, little is known about the clinical values and biological function in clear cell Renal cell carcinoma (ccRCC).

Methods: The expression pattens of NR1H4 in ccRCC were investigated in clinical specimens, cell lines and publicly‑available databases. Cell Counting Kit-8 (CCK-8), colony formation, 5-ethynyl-2' -deoxyuridine (EdU), transwell and cell wound healing assays were performed to assess the biological functions of NR1H4 in 786-O ccRCC cells.

A prognosis model for clear cell renal cell carcinoma based on four necroptosis-related genes.

Necroptosis is a type of caspase-independent cell death, and it plays a critical role in regulating the development of cancer. To date, little is known about the role of necroptosis-related genes (NRGs) in clear cell renal cell carcinoma (ccRCC). In this study, we downloaded data regarding the expression of NRGs and overall survival (OS) from The Cancer Genome Atlas (TCGA) database and constructed a risk model to determine the prognostic features of necroptosis using COX regression analysis.

Pb Responsive Cu-In-Zn-S Quantum Dots With Low Cytotoxicity.

Water-soluble Cu-In-Zn-S quantum dots (CIZS QDs) with orange fluorescence have been synthesized with a glutathione (GSH) as stabilizer via facile a one-step hydrothermal method. The optimal reaction conditions of CIZS QDs including temperature, time, pH, and the molar ratios of precursors were studied. TEM results indicate that the aqueous-dispersible CIZS QDs are quasi-spherical, and the average diameters are 3.