[Occurrence and Distribution of Potential Dangerous Biological Agents in Beijing Suburban Rivers].

Dangerous biological agents （DBAs） refer to microorganisms, toxins, and other biological substances that have the potential to cause significant harm to humans, animals, plants, and the environment. They are the primary target of the prevention and response in China's Biosafety Law, and it is of great importance to clarify the characteristics of DBAs in the Beijing suburban rivers for the insurance of the water safety in Beijing. The typical Beijing suburban rivers （Mangniu River, Chaohe River, and Baihe River） were selected, and the occurrence and distribution of DBAs concerning the molecular biology composition as the nucleic acid （antibiotic resistance genes, ARGs）, nucleic acid and proteins （viruses）, and intact cellular structures （pathogens） were determined based on the metagenomics.

[Effects of Nitrogen Speciation Transformation on Microbial Community Succession in Input Rivers of Miyun Reservoir].

The Miyun Reservoir is the major source of surface drinking water in Beijing. However, the total nitrogen (TN) concentrations in the Miyun Reservoir and inflowing rivers have recently been increasing. In this study, the Mangniu River, a typical inflow river in the upper reaches of the Miyun Reservoir, was selected as the study area to investigate the spatial distribution and transformation of various nitrogen forms from the perspective of microbial community composition and predicting function, aimimg at providing a scientific reference for nitrogen pollution control of the Miyun Reservoir.

[Impacts of Riparian Buffer Zone Type on Reduction in Runoff Pollution in the North Canal River Under Different Rainfall Events].

The impact of non-point source pollution on the water quality of the North Canal River is becoming increasingly prominent. In this study, the riparian buffer zones (RBZ) of the Nansha River and Beisha River, the inlet tributaries of the Shahe Reservoir in the North Canal basin, were selected to investigate the purification effect of riparian buffer zones on runoff pollution during the rainfall process. Two RBZ types, Type I RBZ (levee-flood control retaining wall-woodland-grassland) and Type Ⅱ RBZ (levee-woodland-grassland), were classified by the distribution characteristics of RBZ structure and plant communities in the North Canal River basin.

Acetic acid transporter-mediated, oral, multifunctional polymer liposomes for oral delivery of docetaxel.

Nanoparticle-structuring aimed at the acetic acid (A) transporter on intestinal epithelial cells and tumor cells is a new potential strategy to enhance oral bioavailability and anti-tumor efficacy. In this study, chitosan (CS) was modified with hydrophilic A and hydrophobic lipoic acid (L), to produce ACSL. A novel ACSL-modified multifunctional liposomes (Lip) loaded with docetaxel (DTX; DTX-ACSL-Lip) was then prepared and characterized.

Accurate method of generating infrared imaging features by the angular disturbance of an airborne platform.

The imaging quality of an airborne infrared (IR) system is limited by the angular disturbance of the airborne platform. Based on the full-chain (IR scene-atmosphere-optical system-detector-airborne platform) signal transmission process, this study focused on the low-frequency sinusoidal angular disturbance features of the airborne platform and accurately calculated the point spread function caused by the angular disturbance and the IR imaging features when the IR system's different locations were dynamically simulated in a three-dimensional scene. First, the degradation mechanism of the IR imaging features resulting from the angular disturbance was analyzed from the viewpoint of scene radiation signal transmission and detector sampling.

PEG-PCL modification and intestinal sustained-release of solid lipid nanoparticles for improving oral bioavailability of 2-methoxyestradiol.

The primary purpose of the present study was to design and optimize a solid lipid nanoparticle (SLN) formulation of the poorly water-soluble drug 2-methoxyestradiol (2-ME) to improve its oral bioavailability and prolong the duration of therapeutic drug level. SLN was modified by amphipathic PEG-PCL (PLN) and then encapsulated in pH-sensitive microparticles (MP) by spray drying technology. Several properties of 2-ME PLN-MP were characterized including particle size, drug loading, and drug or PLN release.

Occurrence of antibiotic resistance genes and mobile genetic elements in enterococci and genomic DNA during anaerobic digestion of pharmaceutical waste sludge with different pretreatments.

Pharmaceutical waste sludge harbors large amounts of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), and it is necessary to study the reduction of ARGs and MGEs during sludge treatment. Therefore, the antibiotic resistance phenotypes and genotypes of enterococci, and the ARGs and MGEs in genomic DNA were investigated during anaerobic digestion (AD) with microwave (MW), thermal hydrolysis (TH) and ozone pretreatment. Results showed that sludge pretreatment increased the occurrence of the resistance phenotypes and genotypes of enterococci.

[Effect of Aeration Strategies on Emissions of Nitrogenous Gases and Methane During Sludge Bio-Drying].

The data on nitrogen gas (NH3, N2O, NO) emissions during sludge bio-drying process in China is scarce, especially NO due to its unstable chemical property. In this study, effect of two aeration modes on emissions of methane and nitrogenous gas was compared during the continuous aerated turning pile sludge bio-drying process at full scale. In these two aeration strategies, the one currently used in the plant was set as the control, and the other was set as the test in which the aeration was used for oxygen supply, pile temperature control, and moisture removal in the start-up, middle and final stages, respectively.