NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction.

Aims: The vascular aging process accelerated by type 2 diabetes mellitus (T2DM) is responsible for the elevated risk of associated cardiovascular diseases (CVDs). Metabolic disorder-induced immune senescence has been implicated in multi-organ/tissue damage. Herein, we sought to determine the role of immunosenescence in diabetic vascular aging and to investigate the underlying mechanisms.

[AIDS-related knowledge, attitudes and behaviors: a prevalence survey among 309 homosexual men in a Chinese city].

Objective: To gain an insight into the demographic characteristics and AIDS-related knowledge, attitudes and behaviors of men who have sex with men (MSM) in a Chinese city, and to offer a base for preventive measures against AIDS.

Methods: We carried out a prevalence survey, using "snowball" methods to set up survey sites in the "comrade" community, the "comrades" looking for the respondents by various means.

Results: Among 309 respondents, 265 (85.

[A new mutation in the GJB1 gene of a Chinese family with Charcot-Marie-Tooth disease associated with vocal cord paresis].

Objective: To report an X-linked dominant Charcot-Marie-Tooth disease (CMTX) Chinese family with vocal cord paresis and to identify the mutation of gap junction protein beta 1 gene (GJB1).

Methods: Part of the family members with dysphagia, dysphonia and lethal respiratory failure were studied through flexible laryngoscope, clinical, brain MRI and electrophysiological examinations. After excluding large fragment tandem duplication containing peripheral myelin protein 22 gene (PMP22), direct sequencing was performed to analyze the mutation of the GJB1 gene in 5 patients including the proband, 5 unaffected family members and 50 unrelated healthy individuals.