Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines.

With the COVID-19 pandemic, the importance of vaccines has been widely recognized and has led to increased research and development efforts. Vaccines also play a crucial role in cancer treatment by activating the immune system to target and destroy cancer cells. However, enhancing the efficacy of cancer vaccines remains a challenge.

A Chinese patent medicine's long-term efficacy on non-dialysis patients with CKD stages 3-5: a retrospective cohort study.

Background: Chinese patent medicine is commonly used in China as an important treatment mechanism to thwart the progression of chronic kidney disease (CKD) stages 3-5, among which Niaoduqing granules are a representative Chinese patent medicine; however, its long-term efficacy on CKD prognosis remains unclear.

Methods: Patients were grouped according to Niaoduqing granule prescription duration (non-Niaoduqing granule (non-NDQ) group vs Niaoduqing granule (NDQ) group). Serum creatinine (SCr) variation was compared using a generalized linear mixed model (GLMM).

Depletion of regulatory T cells enhancing the anti-tumor effect of in situ vaccination in solid tumors.

The emergence of immune checkpoint inhibitors (ICIs) has revolutionized the clinical treatment for tumor. However, the low response rate of ICIs remains the major obstacle for curing patients and effective approaches for patients with primary or secondary resistance to ICIs remain lacking. In this study, immune stimulating agent unmethylated CG-enriched (CpG) oligodeoxynucleotide (ODN) was locally injected into the tumor to trigger a robust immune response to eradicate cancer cells, while anti-CD25 antibody was applied to remove immunosuppressive regulatory T cells, which further enhanced the host immune activity to attack tumor systematically.

Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice.

Background: Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health care products, is frequently detected in human blood and urine. Therefore, it has been considered an emerging and potentially toxic pollutant in recent years. Long-term exposure to TCS has been suggested to exert endocrine disruption effects, and promote liver fibrogenesis and tumorigenesis.

[Analysis of the Impact of Fireworks on Air Quality During the Spring Festival in Chengdu from 2019 to 2022].

Based on the observation data of air quality and PM components, the influence of fireworks on pollutant concentrations, PM components, and secondary transformation during the Spring Festival period from 2019 to 2022 in Chengdu were analyzed. The results indicated that the fireworks had a greater impact on the concentration of SO, PM, and PM than the other pollutants. During the centralized discharge of fireworks from 2019 to 2022, the average hourly concentrations of SO, PM, and PM increased by 6.

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy.

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients' response to immune checkpoint blockade (ICB). Thus, restoring the cytotoxic effect of immune cells in the TME is a promising way to improve the efficacy of ICB and overcome primary resistance to immunotherapy.

Cidan Capsule in Combination with Adjuvant Transarterial Chemoembolization Reduces Recurrence Rate after Curative Resection of Hepatocellular Carcinoma: A Multicenter, Randomized Controlled Trial.

Objective: To evaluate the efficacy and safety of Cidan Capsule combined with adjuvant transarterial chemoembolization (TACE) in patients with a high risk of early recurrence after curative resection of hepatocellular carcinoma (HCC).

Methods: A multicenter, randomized controlled trial was conducted in patients with high-risk recurrence factors after curative resection of HCC from 9 medical centers between July 2014 and July 2018. Totally 249 patients were randomly assigned to TACE with or without Cidan Capsule administration groups by stratified block in a 1:1 ratio.

The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is a dominant cause of death and disability worldwide. A sharp increase in intracranial pressure after SAH leads to a reduction in cerebral perfusion and insufficient blood supply for neurons, which subsequently promotes a series of pathophysiological responses leading to neuronal death. Many previous experimental studies have reported that excitotoxicity, mitochondrial death pathways, the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy, and inflammation are involved solely or in combination in this disorder.

[Effects of combined application of biochar with organic amendments on enzyme activity and microbial metabolic function of carbon sources in infertile red soil].

To improve carbon (C) sequestration and soil fertility of red soil, a two-year (2017 and 2018) field experiment was conducted to investigate the effects of two organic amendments (, corn straw and sheep manure) applied alone or combined with biochar on soil nutrient content, enzyme activities involved in C cycling, and microbial substrate utilization rate in infertile red soil. There were six treatments, including control (non-amendment), corn straw, sheep manure and across biochar treatments (without and with biochar amendment, respectively). The organic amendments and biochar were applied in 2017 and 2018.

[Effects of moso bamboo () expansion on soil microbial community in evergreen broad-leaved forest].

The special eco-physiological characteristics of moso bamboo () facilitate their fast invasion in nature ecosystems. The widespread expansion of moso bamboo causes degradation of adjacent forest ecosystem and change of landscape, as well as soil properties and microbial community composition. However, how moso bamboo expansion affects soil microbial composition is far from fully understood.

[Emission Characteristics and Inventory of Volatile Organic Compounds from Cooking in Sichuan Province].

NMHCs concentrations and VOCs components were sampled from 12 typical catering units in Sichuan Province. Combined with literature data, the cooking source profile containing 117 VOCs was established comprehensively, and the NMHCs emission factors were obtained. Based on the bottom-up research method, the volatile organic compounds emission inventory of cooking sources in Sichuan Province was established.

[Characteristics of O Pollution and Key Precursors in Chengdu During Spring].

To study the characteristics of O pollution and identify the key precursors for O formation in Chengdu in spring, O concentrations in April between 2016 and 2018 were analyzed, and on-line measurements of O and the precursors(VOCs and NO) were also studied at an urban site. The results showed that the O pollution level in April increased year by year, and diurnal variations showed a unimodal distribution. When the ambient temperature was more than 20℃, the wind speed was between 1 and 1.

Genomic anatomy of male-specific microchromosomes in a gynogenetic fish.

Unisexual taxa are commonly considered short-lived as the absence of meiotic recombination is supposed to accumulate deleterious mutations and hinder the creation of genetic diversity. However, the gynogenetic gibel carp (Carassius gibelio) with high genetic diversity and wide ecological distribution has outlived its predicted extinction time of a strict unisexual reproduction population. Unlike other unisexual vertebrates, males associated with supernumerary microchromosomes have been observed in gibel carp, which provides a unique system to explore the rationales underlying male occurrence in unisexual lineage and evolution of unisexual reproduction.

Primary intracranial papillary meningioma: Analysis of factors of prognosis and systematic review.

Objective: Papillary meningioma is rare and displays an aggressive clinical behavior with poor prognosis. Therefore, we performed an extensive literature review to evaluate the adverse factors and treatment strategy of survival.

Method: We performed Ovid, Medline, Embase, Pubmed, Web of Science and Cochrane database queries for articles published between 1938 and 2019 with the search term "WHO grade III meningioma" or "papillary meningioma" and "central nervous system", "cerebral", or "intracranial".

Imaging presentation and postoperative recurrence of peliosis hepatis: A case report.

Background: Peliosis hepatis (PH) is a rare benign lesion of vascular origin with a pathological characteristic of multiple blood-filled cavities in the liver parenchyma. It is commonly misdiagnosed due to its lack of specificity in clinical presentation and laboratory test results. Herein, a case of a patient with PH who was misdiagnosed with hepatic echinococcosis before operation to remove the lesions was analyzed, with an emphasis on the computed tomography and magnetic resonance imaging characteristics of PH.

Fitness comparison of on original and marginal hosts using age-stage, two-sex life tables.

The diamondback moth, , is an important agricultural pest that severely damages cruciferous vegetables. Although previously considered a threat only to species, has been observed to feed on noncruciferous vegetables. Here, we established a population of on the pea (PxP population).

[Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].

Objective To explore the function and mechanism of related genes in the occurrence and development of liver cancer, and the possibility of key genes as potential biomarkers and prognostic indicators for the treatment of liver cancer.Methods We selected 4 datasets(GSE57957, GSE121248, GSE36376 and GSE14520)from the GEO database.With <0.

[Sources Apportionment of Oxygenated Volatile Organic Compounds (OVOCs) in a Typical Southwestern Region in China During Summer].

Oxygenated volatile organic compounds (OVOCs) are important intermediates in the troposphere and the most important sources of ozone. Proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) was used to measure VOCs in the Chengdu Plain, Southwestern China. The diurnal variations, photochemical reactivity, O formation potential, and sources were also investigated.

[Trends in Vehicle Emissions in Sichuan Province, 2010-2017].

Vehicle pollution in Sichuan Province is becoming increasingly serious. Here, based on specific inventory calculation methods and multi-caliber activity level data, this study calculated vehicle exhaust emissions from 2010 to 2017 in Sichuan Province. The results show that the average growth rate of vehicle ownership in Sichuan is higher than the national trend.

[Characteristics and Sources of Atmospheric Volatile Organic Compounds Pollution in Summer in Chengdu].

In the research, volatile organic compounds (VOCs) were observed online in urban areas of Chengdu to study VOC concentration level, change characteristics, ozone generation contribution (OFP), and source contribution from June to September 2019. The results showed that the average concentration of TVOCs (total volatile organic compounds) was 112.66 μg·m, with alkanes (29.

Clinical Characteristics of Transarterial Chemoembolization in Treatment of Primary Hepatocellular Carcinoma Complicated With Respiratory Distress Syndrome.

Objective: The present study aims to analyze the clinical characteristics and etiology of transarterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC) complicated with acute respiratory distress syndrome (ARDS), in order to improve the early diagnosis rate and cure rate.

Methods: A total of 816 patients with primary HCC received 2,200 TACE treatments from January 2014 to May 2018. Among these patients, 6 patients developed ARDS after TACE.

[Emission Inventory and Characteristics of Anthropogenic Air Pollution Sources Based on Second Pollution Source Census Data in Sichuan Province].

In this research, the activity data of Sichuan Province were collected using bottom-up and top-down methods. According to the second survey of pollution sources, the activity data of industrial source includes information of 11020 boilers and 60078 industrial enterprises. Data of 19152 industrial enterprises were collected in Chengdu, accounting for 32% of the total number of enterprises in Sichuan Province.

[Characteristics and Formation Mechanism of Three Haze Pollution Processes in Chengdu in Winter].

Based on the online monitoring data of gaseous pollutants and components in PM from Chengdu super observatory of atmospheric environment, the meteorological factors and component characteristics of three haze pollution process in Chengdu from 2019 to 2020 were analyzed. The CMB model was adopted to simulate the sources and variation trends of PM pollution during the study period, and the causes of each pollution process were analyzed. The results showed that all the three pollution processes occurred under adverse meteorological conditions, where the relative humidity and temperature continued to rise and the wind speed and boundary layer height continued to decrease.

[Method for High-resolution Emission Inventory for Road Vehicles in Chengdu Based on Traffic Flow Monitoring Data].

A method for developing a high-resolution emission inventory for road vehicles based on traffic flow monitoring data is proposed in this study. The characteristics of road traffic flow were analyzed and a high-resolution emission inventory of vehicle in Chengdu was established. The results showed that the traffic flow and emissions in Chengdu exhibited an obvious "double peak" distribution, and that the traffic volume of vehicles during peak hours accounted for 39.