Publications by authors named "Jun-di Xie"
Background: Endothelial dysfunction (ED), characterized by markedly reduced nitric oxide (NO) bioavailability, vasoconstriction, and a shift toward a proinflammatory and prothrombotic state, is an important contributor to hypertension, atherosclerosis, and other cardiovascular diseases. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is widely involved in cardiovascular development. Przewaquinone A (PA), a lipophilic diterpene quinone extracted from Salvia przewalskii Maxim, inhibits vascular contraction.
View Article and Find Full Text PDFBackground: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferroptosis has been reported in the SICD. TaoHe ChengQi decoction (THCQD), a classical traditional Chinese medicinal formula, has multiple beneficial pharmacological effects.
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- Myocardial fibrosis is a growing health issue linked to heart attacks (myocardial infarctions), prompting the need for effective treatments.
- This study explores the effects of a natural compound, ethyl ferulate (EF), on the TGF-receptor 1 (TGFBR1) signaling pathway in the context of myocardial fibrosis after a heart attack.
- Results showed that EF reduced fibrosis and improved heart function by inhibiting TGFBR1 signaling, both in live mice and in cell cultures, indicating its potential as a therapeutic agent for heart conditions.