Publications by authors named "Jun-chao Chen"
Article Synopsis
- Current medication guidelines for constipation lack detailed quantitative data on the effectiveness of various drugs regarding bowel movement frequency.
- This study employed a meta-analysis to assess how different medications affect spontaneous bowel movements (SBMs) and complete spontaneous bowel movements (CSBMs) compared to baseline levels.
- Results indicated that bisacodyl significantly increased bowel movement frequency more than other medications, while plecanatide showed the least effect, highlighting notable variations in drug efficacy.
Article Synopsis
- The increasing use of electronic data management (EDC) is transforming how clinical trial data is handled.
- A study analyzed 20 clinical trials with over 5,400 subjects across 321 sites to assess EDC's benefits.
- Findings highlight improvements in data collection, cleaning, quality control, and decision-making in clinical trials, supporting further EDC adoption.
[Comparison of paper and electronic data management in clinical trials].
Yao Xue Xue Bao
November 2015
Article Synopsis
- Investigators and sponsors are shifting from traditional paper case report forms (pCRFs) to electronic case report forms (eCRFs) in clinical research for efficiency.* -
- A comparison of 14 phase III studies (8 using pCRF, 6 using eCRF) indicates that electronic data capture (EDC) offers benefits like improved data quality and quicker clinical decisions.* -
- Effective use of EDC hinges on proper data management processes and the reallocation of resources to support the transition from paper to electronic forms.*
Article Synopsis
- The study highlights the importance of comprehensive data cleansing in clinical trials, utilizing a newly developed visual check approach.
- It reviews 8 types of visual graphics that help identify patterns and relationships in different types of clinical data throughout various stages of data management.
- These graphics enable quick detection of abnormal data, facilitate real-time monitoring of clinical research, and enhance both the efficiency and quality of data in clinical trials.
Purpose: To identify the tolerance of radiation with a high prescribed dose and predictors for the development of intrathoracic stomach toxicity in patients with thoracic esophageal squamous cell carcinoma (SCC) after esophagectomy followed by gastric conduit reconstruction.
Materials And Methods: From 2011 to 2013, 105 patients after esophagectomy were treated with postoperative radiotherapy. The intrathoracic stomach was outlined with the calculation of a dose-volume histogram (DVH) for the initial intended treatment of 6020 cGy or 6300 cGy.
Sample sizes in dosage investigational clinical trials: a systematic evaluation.
Drug Des Devel Ther
September 2015
Article Synopsis
- The primary goal of phase II clinical trials is to assess the effectiveness and optimal dosages of treatments, but there's no established guideline for the ideal sample sizes.
- A review of 2,103 trials revealed that 55% had fewer than 40 participants per group, while only 17.2% exceeded 100 participants.
- Larger sample sizes were more common in parallel study designs compared to crossover designs, highlighting the need for careful consideration of sample size based on study design and objectives.
Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.
In Vitro Cell Dev Biol Anim
August 2014
Extensive and dynamic chromatin remodeling occurs after fertilization, including DNA methylation and histone modifications. These changes underlie the transition from gametic to embryonic chromatin and are thought to facilitate early embryonic development. Histone H3 lysine 4 methylation (H3K4me) is an important epigenetic mechanism that associates with gene-specific activation and functions in development.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how different combinations of active ingredients in Paino Powder (like paeoniflorin and naringin) reduce inflammation in rats using a carrageenin-induced edema model.
- An orthogonal design tested 7 combinations of these ingredients, comparing their effects to control groups of aspirin and saline.
- Results showed that the full 4-ingredient combination was most effective in reducing swelling, with naringin being the most influential component, and validated the use of orthogonal simulation for research purposes.
Comparative pharmacokinetic (PK) analysis is often carried out throughout the entire period of drug development, the common approach for the assessment of pharmacokinetics between different treatments requires that the individual PK parameters, which employs estimation of 90% confidence intervals for the ratio of average parameters, such as AUC and Cmax, these 90% confidence intervals then need to be compared with the pre-specified equivalent interval, and last we determine whether the two treatments are equivalent. Unfortunately in many clinical circumstances, some or even all of the individuals can only be sparsely sampled, making the individual evaluation difficult by the conventional non-compartmental analysis. In such cases, nonlinear mixed effect model (NONMEM) could be applied to analyze the sparse data.
View Article and Find Full Text PDFThe paper aimed to find the optimal combination and evaluation of the interactions of antitumor effect of the curcumin (Cur) and adriamycin (ADM) in vitro. According to the factorial design and data characteristics, the parameter method combined with the response surface approach were used to analyze the pharmacodynamic interactions of in vitro antitumor effects of the combination of Cur and ADM at different dosages. The results showed that the dose-effect relationship of the combination with the ratio of ADM-Cur 1:3 showed significant differences in comparison with either used alone.
View Article and Find Full Text PDFObjective: To study the anti-inflammatory effects of the combinations of active components of Painong powder, a compound traditional Chinese herbal medicine, and the quantitative analysis of their interactions.
Methods: The mouse model of acute inflammation with increase of capillary permeability was induced by intraperitoneal injection of acetic acid. An orthogonal design with 2 levels (used and unused) was applied to assign the combinations groups of active ingredients including naringin and neohesperidin, peoniflorin, and platycodin.
[Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response].
Zhongguo Zhong Yao Za Zhi
August 2008
Objective: An approach is set up to calculate pharmacodynamic interaction and simulate the combined response.
Method: An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach.