Publications by authors named "Jun-bing Guo"
We recently reported that maxillary sinus membrane stem cells (MSMSCs) have osteogenic potential. However, the biological mechanisms of bone formation remain unclear. In this study, we investigated the role and mechanisms of microRNAs (miRNAs) in the osteogenic differentiation of MSMSCs.
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- Maxillary sinus membrane (MSM) elevation is a surgical method used to increase bone height in the upper jaw before dental implants, but the biological process behind bone regeneration in MSM is not well understood.
- This study involved isolating MSM stem cells (MSMSCs) from 16 patients undergoing orthognathic surgery, examining their characteristics such as growth ability, surface markers, potential to mature into different cell types, and their behavior when implanted in living organisms.
- The results indicated that MSMSCs are mesenchymal stem cells with the ability to generate bone-like tissue and retain their stem cell properties, suggesting they could play a key role in bone regeneration for dental implants.
Knockdown of Cdc6 inhibits proliferation of tongue squamous cell carcinoma Tca8113 cells.
Technol Cancer Res Treat
April 2013
Article Synopsis
- The study investigated how reducing Cdc6 affects Tca8113 cell growth by using lentiviral vectors to deliver cdc6 siRNA.
- Real-time PCR and Western blotting showed a significant decrease in both mRNA and protein levels of Cdc6 after infection, with reductions up to 79.38%.
- Results indicated slowed cell growth and altered cell-cycle progression, with fewer cells in the S phase and increased apoptosis in Cdc6 downregulated cells.
Pulmonary metastases from an Ameloblastoma: case report and review of the literature.
J Craniomaxillofac Surg
December 2012
Article Synopsis
- Ameloblastomas are tumors known for high recurrence rates and local invasion, classifying them as borderline tumors, but they rarely metastasize.
- A case study details a patient whose mandibular ameloblastoma came back 29 years after surgery and metastasized to both lungs, making complete surgical removal impossible.
- The pulmonary metastases were confirmed via biopsy and not actively treated; monitoring over four years showed no significant changes in the lung tumors, while recent cases are reviewed regarding their occurrence and treatment.
Purpose: Oral mucositis is a common side effect of radiotherapy for head and neck cancer. The purpose of this study was to examine the significance of and the relationship between hypoxia inducible factor-1alpha (HIF-1alpha) and cyclooxygenase-2 (COX-2) gene expression and the corresponding protein levels in irradiated rat mucosa.
Material And Methods: A Sprague-Dawley rat model of irradiation-induced oral mucositis was generated.