Targeted modulation of gut and intra-tumor microbiota to improve the quality of immune checkpoint inhibitor responses.

Immune checkpoint inhibitor (ICI) therapies, such as those blocking the interaction of PD-1 with its ligands, can restore the immune-killing function of T cells. However, ICI therapy is clinically beneficial in only a small number of patients, and it is difficult to predict post-treatment outcomes, thereby limiting its widespread clinical use. Research suggests that gut microbiota can regulate the host immune system and affect cancer progression and treatment.

Associations between perceived overqualification, transformational leadership and burnout in nurses from intensive care units: A multicentre survey.

Aims: To explore whether perceived overqualification increases the risk of burnout and whether transformational leadership negatively moderates this relationship.

Background: Perceived overqualification might contribute to burnout and lead to poor experience of transformational leadership, and transformational leadership might be associated with burnout. However, these relationships have not yet been confirmed.

Bacteria in cancer therapy: A new generation of weapons.

Tumors are presently a major threat to human life and health. Malignant tumors are conventionally treated through radiotherapy and chemotherapy. However, traditional therapies yield unsatisfactory results due to high toxicity to the normal cells, inability to treat deep tumor tissues, and the possibility of inducing drug resistance in the tumor cells.