Publications by authors named "Jun-Ye Jiang"
Article Synopsis
- - Cyclosporine (CsA) is part of the primary treatment for acquired aplastic anemia in kids, and researchers developed a population pharmacokinetic (PK) model to personalize dosing for Chinese pediatric patients based on their unique characteristics.
- - Data from 681 CsA concentration samples and lab results from 157 patients were analyzed using a nonlinear mixed-effect model, identifying key factors like body weight and total bilirubin levels that affect CsA's behavior in the body.
- - The final PK model indicated that a typical 28 kg child has a clearance rate of 29.1 L/h and a central volume of distribution of 325 L, allowing for tailored CsA therapies while finding that factors like gender and age had
Article Synopsis
- This study develops a population pharmacokinetic (PK) model for high-dose methotrexate (HD-MTX) specifically tailored for Chinese pediatric patients with acute lymphoblastic leukemia (ALL), using data from 311 patients.
- Using NONMEM software, the research includes analysis of 4,517 serum concentration data and identifies how factors like body weight and serum creatinine affect the drug's clearance and distribution.
- The proposed PK model allows for individual parameter estimation, aiming to optimize methotrexate therapy and enhance treatment outcomes while minimizing toxicity in young patients.
Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, while relapse and refractory ALL remains a leading cause of death in children. However, paired ALL samples of initial diagnosis and relapse subjected to next-generation sequencing (NGS) could construct clonal lineage changes, and help to explore the key issues in the evolutionary process of tumor clones. Therefore, we aim to analyze gene alterations during the initial diagnosis and relapse of ALL patients and to explore the underlying mechanism.
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- Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and recent studies have delved into the genetic changes associated with it, but their impact on clinical outcomes remains uncertain.
- A study involving targeted exome sequencing of 140 pediatric patients in China found that T-cell ALL patients had higher initial white blood cell counts, more frequent mediastinal masses, and higher relapse rates correlated with specific genetic mutations.
- The findings indicate that certain genetic mutations and initial white blood cell counts are significant risk factors for relapse and adverse outcomes, suggesting that genetic profiling could enhance prognosis and treatment strategies for ALL patients.
Background: Faba bean (Vicia faba L.) is an important food legume crop, grown for human consumption globally including in China, Turkey, Egypt and Ethiopia. Although genetic gain has been made through conventional selection and breeding efforts, this could be substantially improved through the application of molecular methods.
View Article and Find Full Text PDFPremise Of The Study: Expressed sequence tag (ESTs)-derived microsatellite markers were developed in Lathyrus sativus by screening the National Center for Biotechnology Information (NCBI) database. The usefulness of these novel markers was validated for size polymorphism among grasspea accessions. •
Methods And Results: Three hundred EST-simple sequence repeat (SSR) primer pairs were identified and loci characterized for size polymorphism among 24 grasspea accessions from worldwide sources.