Publications by authors named "Jun-Yao Xiong"
Article Synopsis
- Using high-photoluminescence quantum dots (QDs) to label viruses can help visualize and understand how viral infections work, but current methods struggle to attach to viral components without altering the virus itself.
- * Researchers developed a new method using CRISPR to attach QDs to the nucleic acids of the Pseudorabies virus (PRV) without affecting the viral envelope or capsid.
- * This technique allows real-time tracking of PRV's movement in cells, showcasing its effectiveness for studying viral infection processes in various cell types.
Article Synopsis
- The study investigates the differences between highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) and classical PRRSV, focusing on specific amino acid mutations in nonstructural protein 9 that affect viral replication and pathogenicity.
- Researchers found two critical amino acid mutations at positions 519 and 544, which significantly influence the virus's ability to replicate and cause disease in infected pigs.
- These findings enhance our understanding of PRRSV biology and could lead to improved treatments and prevention strategies for this viral threat to the pig industry.
Vet Microbiol
September 2017
Article Synopsis
- Porcine reproductive and respiratory syndrome (PRRS) has significantly impacted China's swine industry since its emergence in 1996, leading to substantial economic losses.
- A recent study sequenced and analyzed 217 PRRS virus strains, investigated available sequences from 1996-2016, and identified five lineages, with lineage 8 being the most prevalent.
- The research provides a detailed phylogeographical overview of PRRSVs in China, highlights the rise of lineage 1 and lineage 3 strains, and aims to enhance PRRS prevention strategies based on the findings.
