Publications by authors named "Jun-Yan Li"

Article Synopsis
  • Scientists found a long non-coding RNA (lncRNA) called SIMALR that is highly active in a type of throat cancer called nasopharyngeal carcinoma (NPC).
  • SIMALR is important because it helps cancer cells grow and spread, and its high levels can predict worse outcomes for patients.
  • SIMALR works by helping a protein called eEF1A2 to make other proteins faster, which pushes cancer cells to be more aggressive.
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The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE TACE alone and quantifies the differences between these two treatment methods. A systematic search was conducted in multiple databases including PubMed, Cochrane, CNKI, and Wanfang, until 1 July 2023.

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Article Synopsis
  • Docetaxel combined with cisplatin and 5-fluorouracil (TPF) is the main treatment for advanced nasopharyngeal carcinoma (NPC), but some patients do not respond well, with the reasons for this remaining unclear.* -
  • DCAF7 has been identified as a gene that contributes to chemoresistance in NPC by enhancing cisplatin resistance and promoting cell metastasis, functioning as a scaffold protein that stabilizes G3BP1 and helps form stress granules.* -
  • High levels of DCAF7 in NPC patients are associated with a greater risk of metastasis and poorer prognosis, indicating that targeting the DCAF7-USP10-G3BP1 pathway could
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Gemcitabine (GEM) based induction chemotherapy is a standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). However, approximately 15 % of patients are still resistant to GEM-containing chemotherapy, which leads to treatment failure. Nevertheless, the underlying mechanisms of GEM resistance remain poorly understood.

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Article Synopsis
  • Chemoresistance is a significant factor in treatment failure for nasopharyngeal carcinoma, primarily linked to high levels of the E3 ubiquitin ligase PJA1, which is associated with poor response to chemotherapy.
  • PJA1 contributes to resistance by preventing pyroptosis through the degradation of the mitochondrial protein PGAM5, which reduces reactive oxygen species production and hampers the immune response against tumors.
  • Targeting PJA1 with inhibitors like RTA402 shows potential to enhance chemotherapy effectiveness, suggesting that E3 ligases are crucial in managing chemoresistance and can be explored for new treatment strategies.
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T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylinositol (GPI)-linked glycoprotein highly expressed in various cancers, and evaluated its efficacy against solid tumors. CDR walking and phage display techniques were used to improve affinity of the parental antibody M912, resulting in a pool of antibodies with different affinities to MSLN.

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Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients' survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not all patients could benefit from this therapy. The mechanism underlying the TPF chemoresistance remains unclear. Here, by analyzing gene-expression microarray data and survival of patients who received TPF chemotherapy, we identify transcription factor ATMIN as a chemoresistance gene in response to TPF chemotherapy in NPC.

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Introduction: Little research has explored galactagogue food consumption in China. This study aims to investigate consumption patterns and how they relate to perceived insufficient milk supply and exclusive breastfeeding.

Methods: Data were collected from postpartum women in China at six time points: baseline demographic questionnaire before hospital discharge (T0), galactagogue food questionnaire at 1 month postpartum (T1), Hill and Humenick Lactation Scale at 6 weeks postpartum (T2), and breastfeeding practices at 1, 2, 3 and 4 months postpartum (T1, T3, T4, T5).

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Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequencing and T cell and B cell receptor sequencing of matched, treatment-naive and post-GP chemotherapy NPC samples (n = 15 pairs), we show that GP chemotherapy activated an innate-like B cell (ILB)-dominant antitumor immune response.

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The introduction of selenium-containing functional groups into steroids to study the biological activities of related derivatives is rarely reported in the literature. In the present study, using cholesterol as raw material, four cholesterol-3-selenocyanoates and eight B-norcholesterol selenocyanate derivatives were synthesized, respectively. The structures of the compounds were characterized by NMR and MS.

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Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin ligase, tumour cell-intrinsic tripartite motif-containing 21 (TRIM21) in tumours, is inversely associated with the response to radiation and CD8 T cell-mediated antitumour immunity in nasopharyngeal carcinoma (NPC). Knockout of TRIM21 modulates the cGAS/STING cytosolic DNA sensing pathway, potentiates the antigen-presenting capacity of NPC cells, and activates cytotoxic T cell-mediated antitumour immunity in response to radiation.

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Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes, in which circWDR37 is a key regulator. CircWDR37 deficiency limits cisplatin or gemcitabine-induced senescent NPC cells from proliferation, migration, and invasion.

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Background: Returning to work after childbirth is a common reason for women to stop breastfeeding. This study aimed to assess breastfeeding practices and breastfeeding support available to employed women in China, and factors affecting breastfeeding duration.

Methods: A cross-sectional survey of 1,243 breastfeeding women employed full-time was conducted.

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Background: Endoscopy artifacts are widespread in real capsule endoscopy (CE) images but not in high-quality standard datasets.

Aim: To improve the segmentation performance of polyps from CE images with artifacts based on ensemble learning.

Methods: We collected 277 polyp images with CE artifacts from 5760 h of videos from 480 patients at Guangzhou First People's Hospital from January 2016 to December 2019.

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Lead (Pb) is considered to be a major environmental pollutant and occupational health hazard worldwide which may lead to neuroinflammation. However, an effective treatment for Pb-induced neuroinflammation remains elusive. The aim of this study was to investigate the mechanisms of Pb-induced neuroinflammation, and the therapeutic effect of sodium para-aminosalicylic acid (PAS-Na, a non-steroidal anti-inflammatory drug) in rat cerebral cortex.

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Importance: Microbiota-tumor interactions have qualified microbiota as a promising prognostic biomarker in various types of cancers. Although the nasopharynx acts as a crucial niche of the upper respiratory tract microbiome, whether the intratumoral microbiota exists and its clinical significance in nasopharyngeal carcinoma (NPC) remain uncertain.

Objective: To evaluate the clinical significance of intratumoral microbiota for individual prognostication in patients with NPC.

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Increasing evidence has revealed the roles of long noncoding RNAs (lncRNAs) as tumor biomarkers. Here, we introduce an immune-associated nine-lncRNA signature for predicting distant metastasis in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The nine lncRNAs are identified through microarray profiling, followed by RT-qPCR validation and selection using a machine learning method in the training cohort (n = 177).

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Background: Studies are trying to add immunotherapy to gemcitabine and cisplatin (GP) induction chemotherapy, the standard therapy, in nasopharyngeal carcinoma (NPC) patients with locoregionally advanced disease. However, how the immune system responds to GP remains unknown.

Method: We examined the dynamic changes of circulating immune cells and plasma cytokines in NPC patients administered with GP.

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Previous studies have investigated influencing factors of early discontinuation of breastfeeding, but few studies have developed an easy-to-use tool to identify risk of breastfeeding cessation at 6 months after birth. This research team aimed to develop and validate an exclusive breastfeeding duration risk nomogram in Chinese mothers. A longitudinal cohort survey was conducted.

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Article Synopsis
  • The study focuses on the spatial distribution of lymphocytes and cancer cells within the tumor microenvironment of nasopharyngeal carcinoma (NPC) patients and its relevance to clinical outcomes.
  • Researchers analyzed immunohistochemistry images from 336 NPC patients to create cell density maps and used hotspot analysis to identify areas with high concentrations of cancer and immune cells.
  • Results indicated that immune-cancer hotspots were linked to worse overall survival, while higher immune hotspot scores correlated with better survival rates, suggesting that spatial analysis can provide valuable prognostic information for NPC patients.
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Article Synopsis
  • Aneurysmal subarachnoid hemorrhage (aSAH) is a serious brain condition caused by bleeding and can lead to issues like working memory (WM) problems even in survivors.
  • Researchers studied 50 aSAH patients to understand how different parts of the brain work together when they are at rest, especially those with WM deficits.
  • They found that certain brain connections were weaker in patients with memory problems, suggesting new ways to help improve brain function through stimulation treatments.
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Background And Aims: The relationship between prior breastfeeding experience and the duration of exclusive breastfeeding is of significant interest, but few studies have explored the mechanisms underlying this relationship. The purpose of this study is to address two hypotheses: (a) that attitude and self-efficacy mediate the relationship between previous breastfeeding experience and the duration of exclusive breastfeeding; and (b) that attitude and self-efficacy have serial mediation functions in this relationship.

Methods: The data collection process was divided into two stages.

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Parabronemosis is a disease that severely threatens camel health, causing huge economic losses to industries involved in camel husbandry. Previous studies have reported that horn flies (Haematobia irritans) act as intermediate hosts of Parabronema skrjabini; however, the infection and developmental processes of P. skrjabini in horn flies remain unclear.

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