Publications by authors named "Jun-Ya Jia"
Article Synopsis
- - The study investigates the role of dendritic cells (DCs) in crescentic glomerulonephritis (CrGN) by examining their distribution in kidney tissues from 26 patients with the disease using immunofluorescence staining techniques.
- - Findings reveal that DC subsets are mostly located in the kidney interstitium, especially around the glomeruli, and their presence increases in CrGN patients, with variations depending on the specific type of CrGN.
- - The results suggest that higher numbers of certain DC subsets are related to more severe kidney damage, indicating that these immune cells may play a significant role in the progression of CrGN.
Article Synopsis
- The study investigates the causal link between gut microbiota and Behçet's disease (BD), using advanced statistical methods from large-scale genetic data.
- Results indicate that certain gut bacteria, like Parasutterella and Lachnospiraceae, may protect against BD, while Intestinibacter could increase risk.
- The findings suggest that specific gut microbiota could serve as biomarkers and potential treatment targets for managing BD.
Background: Cathepsins have been recently identified as a regulator in the activation of Th1 and Th17 cells, which play an important role in the pathogenesis of anti-glomerular basement membrane (GBM) disease. Whether cathepsins contribute to the development of anti-GBM disease through regulating the activation of CD4 T cell is still unclear.
Methods: Rats with experimental anti-GBM disease was established by immunization with the nephritogenic T cell epitope α3.
Background: Thyroid dysfunction is common in patients with nephrotic syndrome, especially patients with primary membranous nephropathy (pMN). In view of both MN and thyroid dysfunction are associated with autoimmunity, the current study aimed to elucidate the significance of thyroid dysfunction in patients with pMN.
Methods: Four hundred and twenty patients with biopsy-proven pMN from 2018-2021 were retrospectively enrolled.
Article Synopsis
- - This study investigates the roles of S100A8/A9 and S100A12 in patients with MPO-ANCA-positive vasculitis, focusing on their potential impact on disease progression and severity.
- - Researchers assessed blood and urine levels of these proteins in 42 AAV patients and discovered that higher levels were linked to more severe disease compared to inactive AAV or healthy controls.
- - The findings suggest that S100A8/A9 and S100A12 could be important biomarkers for AAV and may contribute to the disease's development through specific pathways in activated neutrophils.
Article Synopsis
- * Elevated ND6 levels are linked to severe outcomes, such as the need for hemodialysis and pulmonary hemorrhage, with significant correlations to kidney damage and disease activity.
- * High ND6 levels in AAV patients predict poorer prognosis and increased mortality, indicating its potential as a biomarker for disease severity and organ injury.
Article Synopsis
- The study investigated the relationship between serum hepcidin levels and anemia in patients newly diagnosed with myeloperoxidase (MPO)-ANCA-associated vasculitis (AAV).
- Out of 64 patients, 23 were found to have anemia, which was linked to higher disease activity scores, lower serum iron levels, and elevated ferritin compared to non-anemic patients.
- Results indicated that higher hepcidin levels were associated with anemia, and treatment with immunosuppressives improved iron levels quickly but resulted in slower recovery of hemoglobin.
Severe acute interstitial nephritis induced by valsartan: A case report.
Medicine (Baltimore)
February 2019
Rationale: Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitial nephritis (AIN) induced by valsartan was reported here.
Patient Concerns: A 62-year-old female with nausea for 1 month and acute deterioration of kidney function for 2 weeks was admitted.
Article Synopsis
- The case discusses a 64-year-old female patient who initially presented with kidney issues and was found to have ANCA-negative renal-limited vasculitis, later evolving into ANCA-positive vasculitis over 18 months.
- The transformation from ANCA-negative to ANCA-positive vasculitis was confirmed through subsequent kidney biopsies and detection of antibodies, highlighting a potential process known as epitope spreading.
- The patient responded well to glucocorticoid treatment, showed improvement in kidney function with no relapses during a 6-month follow-up, emphasizing the importance of thorough ANCA testing in diagnosis and management.
Aims: Growing evidences suggest that acute hyperglycemia is strongly related to kidney injury. Our study aimed to investigate the effects of acute hyperglycemia on kidney glomerular and tubular impairment in non-diabetic conscious rats.
Methods: Non-diabetic conscious rats were randomly subjected to 6h of saline (control group) or high glucose (acute hyperglycemia group) infusion.
Membranous nephropathy (MN) is a rare manifestation of IgG4-related disease. Interestingly, the significance of IgG4 has also been documented in idiopathic MN (IMN). Previous studies reported that urine IgG4/IgG ratios were significantly higher in IMN compared with other kinds of nephropathy, indicating that impairment of charge selectivity barrier seemed to be an obvious characteristic of IMN.
View Article and Find Full Text PDFAim: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been proposed to be the replacement of renal osteodystrophy by the Organization of Kidney Disease: Improving Global Outcomes since 2005 because the mineral disorder is not confined to the skeleton in CKD. Accordingly, laboratory and imaging tests have been emphasized for the clinical assessment of patients with CKD besides renal biopsy. The objective of the current study was to investigate whether osteoprotegerin (OPG) could be made a useful biomarker for early diagnosis of CKD-MBD.
View Article and Find Full Text PDF[The role of aldosterone in uremic vascular calcification in patient with end-stage renal disease].
Sheng Li Ke Xue Jin Zhan
October 2010
[The histological changes in radial artery in uremia and their effects on arterial stiffness].
Zhonghua Nei Ke Za Zhi
July 2010
Objective: To examine the changes of histological parameters of radial artery in uremia, and to explore their effects on arterial stiffness.
Methods: Sixty uremic patients underwent arteriovenous fistula surgery for hemodialysis and 20 healthy subjects received healthy examination were collected as uremia group and control group, respectively. Segments of radial arteries were obtained from all of uremic subjects and were evaluated by HE, Masson, van Kossa staining and electron microscopy.
[Physiological and pathophysiological function of local tissue renin-angiotensin system in kidney].
Sheng Li Ke Xue Jin Zhan
January 2008
[Update of the signal transduction pathway of nephrin and its regulation mechanism].
Sheng Li Ke Xue Jin Zhan
July 2006