Publications by authors named "Jun-Xue Qiao"
Article Synopsis
- Wolbachia is a type of bacteria that infects insects and affects their reproduction, primarily through a phenomenon called cytoplasmic incompatibility (CI), where uninfected eggs fail to develop when fertilized by infected sperm.
- The study used advanced metabolomics techniques to identify 414 metabolites whose levels changed due to Wolbachia infection in male flies, showing that the bacteria impact various metabolic pathways, including those related to energy and nutrient metabolism.
- Further analysis indicated that Wolbachia infection leads to increased energy use and oxidative stress in hosts, resulting in defects in sperm development and reduced egg hatch rates, highlighting the role of metabolism in paternal reproductive issues.
Wolbachia are Gram-negative endosymbionts that are known to cause embryonic lethality when infected male insects mate with uninfected females or with females carrying a different strain of Wolbachia, a situation characterized as cytoplasmic incompatibility (CI). However, the mechanism of CI is not yet fully understood, although recent studies on Drosophila melanogaster have achieved great progress. Here, we found that Wolbachia infection caused changes in the expressions of several immunity-related genes, including significant upregulation of kenny (key), in the testes of D.
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