Publications by authors named "Jun-Xiang Peng"
Article Synopsis
- Understanding the differences between suprasellar papillary (PCPs) and adamantinomatous (ACPs) craniopharyngiomas is essential for effective treatment and management strategies.
- A study reviewing 24 PCPs and 52 ACPs revealed that PCPs more often occupy the third ventricle and present distinct patterns of optic chiasm distortion and better postoperative outcomes.
- The findings suggest PCPs are less invasive and more manageable for complete removal, leading to improved hypothalamic function compared to ACPs.
Background: Craniopharyngioma represents a troublesome tumor of the intracranial sellar region. There are currently no available well-characterized craniopharyngioma cell lines. This lack of reliable, immortal cell lines is a major reason for the slow progress in fundamental research related to craniopharyngioma.
View Article and Find Full Text PDFArticle Synopsis
- Adamantinomatous craniopharyngioma (ACP) is a benign tumor in the sellar region, and researchers are exploring whether primary human cell cultures of craniopharyngiomas can serve as a stable model for studying this tumor.
- Three different cultured primary cell lines were analyzed over 10, 20, and 30 days, with various immunofluorescence and transcriptomic differences noted between the cultured cells and original tumor tissues.
- While the cell cultures retained some original epithelial markers, the correlation of gene expression with ACP tissues decreased over time, showing that although differences in gene sets increased with longer culture durations, the primary cultures could still be a viable research tool but need additional validation.
Objective: Nuclear β-catenin, a hallmark of active canonical Wnt signaling, can be histologically detected in a subset of cells and cell clusters in up to 94% of adamantinomatous craniopharyngioma (ACP) samples. However, it is unclear whether nuclear β-catenin-containing cells within human ACPs possess the characteristics of tumor stem cells, and it is unknown what role these cells have in ACP.
Methods: Primary ACP cells were cultured from 12 human ACP samples.
The aim of this study was to clarify pathological and anatomical relationships between adamantinomatous craniopharyngiomas (ACP) and their surrounding structures. We previously established a QST classification scheme based on the apparent anatomic origin of the tumors. According to this classification, 13 type Q tumors, 6 type S tumors, and 42 type T ACPs were analyzed.
View Article and Find Full Text PDFWhether a mixed type of craniopharyngioma (CP) exists and whether papillary craniopharyngioma (pCP) is on a histopathological continuum with Rathke's cleft cyst (RCC) remain controversial. Herein, we examined the expression and localization of β-catenin, BRAF p.V600E (V600E), and triggering receptor expressed on myeloid cells-1 (TREM-1) in 58 samples including 20 pCPs, 26 adamantinomatous craniopharyngiomas (aCP), and 12 RCCs.
View Article and Find Full Text PDFOBJECT Craniopharyngiomas are associated with a high rate of recurrence. The surgical management of recurrent lesions has been among the most challenging neurosurgical procedures because of the craniopharyngioma's complex topographical relationship with surrounding structures. The aim of this study was to define the determinative role of the site of origin on the growth pattern and clinical features of recurrent craniopharyngiomas.
View Article and Find Full Text PDFObject: The aim of this study was to describe the similarity of configuration between the arachnoid complex in the posterior half of the incisural space and the Liliequist membrane.
Methods: Microsurgical dissection and anatomical observation were performed in 20 formalin-fixed adult cadaver heads. The origin, distribution, and configuration of the arachnoid membranes and their relationships with the vascular structures in the posterior half of the incisural space were examined.
Background: Most indices for evaluating a diagnostic test can be expressed as functions of sensitivity (SEN) and specificity (SPE). Practically, all existing methods suffer from the inability to weight sensitivity and specificity relative to their importance. In this paper, we developed a novel index, the weighted Youden index, that allows Youden index to be a combination of sensitivity and specificity with user-defined weights.
View Article and Find Full Text PDFPurpose: In previous studies, some disagreements regarding the nature (inner or outer arachnoid membrane) and lateral boundaries (temporal uncus or tentorial edge) of Liliequist's membrane remain. The aim was to clarify whether Liliequist's membrane is an inner or outer arachnoid membrane, and the distribution of Liliequist's membrane with emphasis on its lateral attachments.
Methods: Liliequist's membrane was investigated by microsurgical dissection in 24 formalin-fixed adult cadaver heads and by histological sections of sellar-suprasellar specimens from another four formalin-fixed adult cadaver heads.