Publications by authors named "Jun-Xian Xu"
Kidney Blood Press Res
November 2022
Article Synopsis
- Sepsis is a major cause of death in critically ill patients and is linked to acute kidney injury (AKI), but the underlying mechanisms are not fully understood.
- This study examined the impact of endothelial dysfunction in sepsis-related AKI and evaluated the effects of a specific PI3Kγ inhibitor on kidney damage and endothelial injury in a mouse model.
- Findings revealed that endothelial damage was significantly worse in sepsis-induced AKI, and inhibiting PI3Kγ helped protect and repair kidney endothelium through the Akt signaling pathway, suggesting new treatment targets.
