NHPI-Mediated FeTiO-Photocatalyzed Semiheterogeneous Decarboxylative Acylarylation of Acrylamides with α-Oxocarboxylic Acids under Nitrogen.

FeTiO has emerged as an interesting semiconductor photocatalyst in organic synthesis. We herein describe a visible-light-induced semiheterogeneous strategy for the synthesis of 3-(2-oxoethyl)indolin-2-ones with moderate to good yields and good functional group compatibility using recyclable FeTiO as a photocatalyst and NHPI as a redox catalyst.

[Effects of Low-dose Antibiotic Exposure on Fetal Growth and Development].

Objective To analyze maternal blood exposure to non-therapeutic antibiotics in late pregnancy and explore the effects of low-dose antibiotics on fetal growth and development.Methods A total of 104 pregnant women in late pregnancy (28-32 weeks) without serious pregnancy complications were enrolled,who had regular antenatal examination and delivery in Peking Union Medical College Hospital and did not use therapeutic antibiotics 2 months before pregnancy and in the whole pregnant process.The levels of antibiotics in the maternal blood were detected by liquid chromatography-tandem mass spectrometry,and the pregnant women were assigned into an antibiotic exposure group (antibiotic positive) and a non-exposure group (antibiotic negative).

Association of gestational anemia with pregnancy conditions and outcomes: A nested case-control study.

Background: Gestational anemia is a serious public health problem that affects pregnant women worldwide. Pregnancy conditions and outcomes might be associated with the presence of gestational anemia. This study investigated the association of pregnancy characteristics with anemia, exploring the potential etiology of the disease.

Maternal Serum Angiogenic Factor sFlt-1 to PlGF Ratio in Preeclampsia: A Useful Marker for Differential Diagnosis and Prognosis Evaluation in Chinese Women.

The ratio of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) is elevated and proved to be useful in preeclampsia (PE) diagnosis. Its value in differential diagnosis with other pregnancy complications and prediction of pregnancy duration has yet to be clarified in Chinese population. We retrospectively analyzed 118 singleton pregnancies with suspected or diagnosed PE at the Peking Union Medical College Hospital (PUMCH) in China.

Preterm Births in Peking Union Medical College Hospital in the Past 25 Years.

Objective To investigate the changes in preterm birth rate,its gestational age distribution,and possible contributors in Peking Union Medical College Hospital (PUMCH) over the last 25-year period. Methods The clinical data of premature deliveries,both singleton and twins,in PUMCH from January 1,1990 to December 31,2014 were retrospectively analyzed. We counted the number of premature fetuses and assessed the changes of preterm birth rate and its gestational age distribution (including extremely preterm birth,early preterm birth,and late preterm birth) over time.

Functionalized graphene-based biomimetic microsensor interfacing with living cells to sensitively monitor nitric oxide release.

It is a great challenge to develop electrochemical sensors with superior sensitivity that concurrently possess high biocompatibility for monitoring at the single cell level. Herein we report a novel and reusable biomimetic micro-electrochemical sensor array with nitric oxide (NO) sensing-interface based on metalloporphyrin and 3-aminophenylboronic acid (APBA) co-functionalized reduced graphene oxide (rGO). The assembling of high specificity catalytic but semi-conductive metalloporphyrin with high electric conductive rGO confers the sensor with sub-nanomolar sensitivity.

Obstetric outcomes in Chinese women with endometriosis: a retrospective cohort study.

Background: The effect of endometriosis on obstetric outcomes is still ambiguous. The aim of our study was to determine the association between endometriosis and adverse obstetric outcomes in a cohort of Chinese women.

Methods: A retrospective cohort study was undertaken to compare obstetric outcomes between 249 women with endometriosis and 249 women without endometriosis.

Removal of transition metal ions from aqueous solution using dialdehyde phenylhydrazine starch as adsorbent.

Dialdehyde phenylhydrazine starch (DASPH) was synthesized by reacting dialdehyde starch (DAS) with phenylhydrazine (PH) and it was characterized by Brunauer-Emmett-Teller (BET), scanning electron microscope, Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) techniques. FT-IR of DASPH revealed the incorporation of the Schiff Base group (C = N) group and the disappearance of the C = O (carbonyl) group. The adsorption behaviors of transition metal ions (Cd(2+), Zn(2+), Pb(2+) and Cu(2+)) were investigated as a function of pH and adsorption time.

Real-time monitoring of auxin vesicular exocytotic efflux from single plant protoplasts by amperometry at microelectrodes decorated with nanowires.

Recent biochemical results suggest that auxin (IAA) efflux is mediated by a vesicular cycling mechanism, but no direct detection of vesicular IAA release from single plant cells in real-time has been possible up to now. A TiC@C/Pt-QANFA micro-electrochemical sensor has been developed with high sensitivity in detection of IAA, and it allows real-time monitoring and quantification of the quantal release of auxin from single plant protoplast by exocytosis.

TIAM2 enhances non-small cell lung cancer cell invasion and motility.

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells.

Materials And Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2.

Genetic counseling, prenatal screening and diagnosis of Down syndrome in the second trimester in women of advanced maternal age: a prospective study.

Background: The incidence of autosomal trisomy in livebirths is strongly dependent on maternal age. Special consideration is given to the provision of prenatal screening and cytogenetic testing to women of advanced maternal age (AMA). The aim of this study was to evaluate the effectiveness of second trimester prenatal screening and amniocentesis for Down syndrome (DS) and compare the trends of choice of screening and amniocentesis among AMA women.

[Management of invasive cervical cancer in pregnancy: clinical analysis of 13 cases].

Objective: To analyze the clinical characteristics and assess the outcome of treatment for cervical cancer during pregnancy.

Methods: A cohort of 13 patients with cervical cancer diagnosed during pregnancy from January 2001 to September 2011 in Peking Union Medical College Hospital (PUMCH) was retrospectively studied. Clinical information, gestational age at diagnosis, treatment options and maternal and child outcomes were collected and analyzed.

[Clinical analysis of pregnancies after vaginal radical trachelectomy].

Objective: To explore the pregnancy outcome and obstetric management of pregnancy and delivery after vaginal radical trachelectomy (VRT).

Methods: Forty-two cases of VRT from December 2003 to May 2012 in Peking Union Medical College Hospital were analyzed retrospectively. Among them ten cases got pregnant successfully.

Preparation and adsorption properties of dialdehyde 8-aminoquinoline starch.

Dialdehyde 8-aminoquinoline starch (DASQA) was synthesized by the reaction of dialdehyde starch (DAS) and 8-aminoquinoline and was used to adsorb various ions from aqueous solution. DASQA was characterized by Fourier transform infrared (FT-IR) spectra, thermogravimetric analysis, X-ray diffraction analysis. The adsorption properties of the polymer for Pb(2+), Cu(2+), Cd(2+), Ni(2+), and Zn(2+) were investigated.

[Pregnancy outcomes of eight pregnant women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency].

Objective: To investigate the clinical features and pregnant outcomes of the pregnant women with congenital adrenal hyperplasia (CAH) 21-hydroxylase deficiency (21-OHD).

Methods: The clinical features, therapies, pregnant outcomes of the pregnant women with 21-OHD were retrospectively reviewed in Peking Union Medical College Hospital, from January 2005 to April 2011.

Results: There were 8 pregnant women with 21-OHD including 5 simple virilizing patients and 3 nonclassical 21-OHD women.

Clinical analysis of placenta previa complicated with previous caesarean section.

Objective: To investigate the clinical features and treatment of placenta previa complicated with previous caesarean section.

Methods: The clinical data of 29 patients with placenta previa complicated with a previous caesarean section (RCS group) admitted in Peking Union Medical College Hospital during a period from 2003 to 2011 were retrospectively reviewed and compared with those of 243 patients with placenta previa without a previous caesarean section (FCS group) during the same period.

Results: There was no difference in the mean age (28.

Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women.

Objective: To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus (GDM) in pregnant Chinese women.

Methods: A nested case-control study was conducted. Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance (NGT).

[Management of pregnancy with myasthenia gravis: 7 cases report].

Objective: To discuss the interaction of pregnancy and myasthenia gravis (MG) and the management of pregnancy with MG.

Methods: Seven cases of pregnancy with MG in Peking Union Medical College Hospital were analyzed retrospectively, with respect to the therapy of MG, pregnancy complications and outcomes.

Results: Totally 38,683 pregnant women were admitted to Peking Union Medical College Hospital between Oct.

Management of pregnancy with ankylosing spondylitis.

Objective: To discuss the interaction between pregnancy and ankylosing spondylitis, and the management of pregnancy with ankylosing spondylitis.

Methods: Twelve cases of pregnancy with ankylosing spondylitis in Peking Union Medical College Hospital from September 2004 to July 2011 were analyzed retrospectively, focusing on the arteritis condition, pregnancy complications, and outcomes.

Results: All the 12 patients had full-term pregnancy.

Adsorption of Zn(II) on dialdehyde m-phenylenediamine starch.

A new chelating material dialdehyde m-phenylenediamine starch (DASMPA) was synthesized by reacting m-phenylenediamine with dialdehyde starch. The obtained material was characterized by element analysis and Fourier transform infrared (FT-IR) spectra. The FT-IR of DASMPA showed an absorption peak at 1605.

Effects of variation in retinol binding protein 4 gene and adipose specific expression of gestational diabetes in Beijing, China.

Objective: To investigate the clinical features of GDM in China and the effects of RBP4 genetic variants, and also to identify RBP4 expression changes in mRNA and protein levels.

Research Design And Methods: 1595 Chinese pregnant women were included in this study. Four known RBP4 single nucleotide polymorphisms (SNPs) were genotyped in 505 cases and 687 controls.

Cytogenetic and clinical analysis of 340 Chinese patients with primary amenorrhea.

Objective: To analyze the relationship between karyotypes and clinic features of patients with primary amenorrhea.

Methods: G banding was done for 340 patients with primary amenorrhea to facilitate individual chromosome identification, and if specific staining for certain portions of the chromosome was necessary, C banding was used. The clinical data were recorded by physical examination and ultrasound scanning.

[Establishment of multiple quantitative fluorescent polymerase chain reaction assay and its application in rapid prenatal diagnosis of common chromosome aneuploidies].

Objective: To establish the multiple quantitative fluorescent polymerase chain reaction (QF-PCR) assay and evaluate its clinical application in prenatal diagnosis.

Methods: Totally 170 samples were collected between May 2008 and July 2009 in prenatal center of Peking Union Medical College Hospital; 123 of them were amniotic fluid, 9 were chorionic villous samples, 20 were fetal blood and 18 were villi from aborted fetuses. All samples were from women of Han nationality, with mean age of (34.