Iron Dysregulation in Parkinson's Disease: Focused on the Autophagy-Lysosome Pathway.

Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc). Although both iron accumulation and a defective autophagy-lysosome pathway contribute to the pathological development of PD, the connection between these two causes is poorly documented. The autophagy-lysosome pathway not only responds to regulation by iron chelators and channels but also participates in cellular iron recycling through the degradation of ferritin and other iron-containing components.

[Denitrification on secondary effluent of acrylic fiber wastewater by tri-stage biofilm advanced reactor].

To resolve the shortage of carbon source during traditional denitrification used to treat secondary effluent of acrylic fiber wastewater, tri-stage biofilm reactor was used, the influence of pH of influent, HRT, and NH4(+) -N concentration in raw water on NH4(+) -N removal was investigated. Efficiency of TN removal was also investigated. It demonstrated that the optimal HRT and pH were 24 hours and 7.

[Characterization of soil humus by FTIR spectroscopic analyses after being inoculated with different microorganisms plus wheat straw].

The effects of different microbial communities on the structural characteristics of humus from the black soil amended with wheat straw were studied by FTIR Spectroscopy. The results indicated that (1) The structure and amount of functional groups in the water soluble substances (WSS) was tremendously influenced by the tested microorganisms, of which the amino and aryl ether was degraded rapidly in the inoculation process, and in the meantime, the content of hydroxyl groups was significantly reduced. The bacteria was helpful to increasing the amount of aliphatic hydrocarbons, while the other inoculated treatments were contrary.