Publications by authors named "Jun-Rui Pei"
Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023.
Biomed Environ Sci
September 2024
Article Synopsis
- - The study aimed to investigate the characteristics and current epidemic situation of Kashin-Beck disease (KBD) among children in China, with the goal of informing prevention and control strategies.
- - Monitoring methods have spanned from fixed-point to full coverage since 1990, with regular clinical and X-ray assessments for children aged 7-12 to confirm KBD diagnoses.
- - Over the years, the prevalence of KBD significantly decreased from 21.01% in 1990 to 0% since 2019 in the monitored areas, indicating successful elimination, although adult cases still require attention.
Background: Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA). Therefore, this study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD.
View Article and Find Full Text PDFEpidemiological investigations indicate that certain ingredients in tea bricks can antagonize the adverse effects of fluoride. Tea polyphenols (TPs), the most bioactive ingredient in tea bricks, have been demonstrated to be potent bone-supporting agents. ClC‑7 is known to be crucial for osteoclast (OC) bone resorption.
View Article and Find Full Text PDFObjective: To explore the inhibitory effect of integrin-linked kinase antisense oligonucleotide (ILK-ASODN) on cell proliferation in human ovarian cancer cell line (HO8910).
Methods: We transfected ILK-ASODN into HO8910 to block ILK gene expression, measured the expression levels of integrin-linked kinase (ILK) mRNA by RT-PCR and ILK protein by western-blotting; the inhibiting effects of the transfection on HO8910 proliferation, the cell cycles, and cell apoptosis were assessed by water soluble tetrazolium-1 (WST-1) and flow cytometry (FCM).
Results: After transfection of ILK-ASODN, the expression levels of ILK mRNA decreased significantly in groups D, E, F being 0.