Publications by authors named "Jun-Ru Ye"

Purpose: The objective of this study was to investigate the influence of photodynamic therapy (PDT) employing different, lower 5-aminolevulinic acid (ALA) dosages on the proliferative activity of Cutibacterium acnes (C. acnes).

Methods: In this in vitro bacterial experiment, we examined the effects of PDT using different doses of ALA (0.

View Article and Find Full Text PDF
Article Synopsis
  • - The study compares the effectiveness of metagenomic next-generation sequencing (mNGS) and traditional pathogen detection methods in diagnosing local pulmonary infections in patients who underwent CT-guided lung biopsies.
  • - Out of 106 patients reviewed, mNGS showed a higher sensitivity in detecting bacterial infections and mixed infections compared to conventional examinations (CE), although it was less effective for fungal and Mycobacterium infections.
  • - mNGS significantly outperformed CE in diagnosing lung abscesses, detecting 67.7% of cases versus 29.0% by CE, highlighting its potential advantages in identifying complex infections.
View Article and Find Full Text PDF

Background: Langerhans cell histiocytosis (LCH) is a rare condition wherein Langerhans cells proliferate abnormally, adversely impacting organs including lymph nodes, bones, skin, lungs, and pituitary gland. The LCH disease course varies widely among patients from a self-limiting condition to one that progresses rapidly and culminates in death. It is uncommon for multisystem LCH to be observed in adults.

View Article and Find Full Text PDF

Background: Patients with high-titer anti-IFN-γ autoantibodies present disseminated non-tuberculous mycobacterial (NTM) and other opportunistic infections. Due to its rare occurrence and non-specific symptoms, this syndrome is difficult to diagnose during early disease stages. Here, we report a case with high-concentrations of serum anti-IFN-γ autoantibodies who presented with disseminated and NTM disease accompanied Sweet's syndrome.

View Article and Find Full Text PDF

Background: Clinicians may fail to make an early diagnosis of pulmonary cryptococcosis (PC) without HIV infection. Serum cryptococcal capsular polysaccharide antigen (CrAg) test, histopathology and culture of lung tissue play different roles in diagnosis of PC.

Objective: To investigate the performance of serum CrAg test, histopathology and culture of the lung tissue in diagnosis of PC without HIV infection.

View Article and Find Full Text PDF

The aim of this study was to identify the optimal cut-off value of T cell enzyme-linked immunospot assay for tuberculosis (T-SPOT.TB) and evaluate its diagnostic performance alone (in the peripheral blood) or in combination with the adenosine deaminase (ADA) activity test (in peripheral blood and the pleural fluid) in patients with tuberculous pleurisy.Adult patients presenting with pleural effusion were included in this prospective cohort study.

View Article and Find Full Text PDF

Multiple myeloma (MM) is characterized by abnormal proliferation of neoplastic plasma cells. Pleural effusion as an initial presentation of this disease is rare, as is true pleural myeloma. We herein present a case of solitary pleural myelomatous lesion in a 70-year-old male patient diagnosed by pleural biopsy via semi-rigid thoracoscopy followed by histopathological examination.

View Article and Find Full Text PDF

Objective: To explore the bronchoscopic and CT findings of invasive tracheobronchial and pulmonary aspergillosis in patients without immunodeficiency.

Methods: Clinical data and bronchoscopic and CT findings of 6 patients with tracheobronchial and pulmonary aspergillosis were reviewed from January 2004 to August 2008.

Results: All the patients had no immunodeficiency diseases.

View Article and Find Full Text PDF