Publications by authors named "Jun-Ren Fang"
Background: Keloid, scar caused by atypical wound repair, represents a significant difficulty for specialists in plastic surgery and dermatology. Adipose-derived mesenchymal stem cells (ADSCs) can regulate fibrotic phenotypes of keloid fibroblasts (KFs) in a paracrine fashion, but whether small extracellular vesicles (SEVs) are the key functional carrier in ADSC paracrine regulation of KFs remains unknown. This study aims to explore whether the regulatory effects of conditioned medium (CM) obtained from ADSCs on KFs can be impaired by decreased SEV content in the ADSC-CM.
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- - The study evaluates the effects of Adipose-derived mesenchymal stem cell-derived exosomes (ADSC-Exos) on the survival of cryopreserved fat grafts, which typically face challenges like rapid absorption and fibrosis.
- - In experiments involving nude mice, cryopreserved fat grafts treated with ADSC-Exos showed improved fat integrity and reduced fibrosis in the short term (up to 4 weeks), but not beyond that, indicating a decline in effectiveness over time.
- - Overall, while ADSC-Exos may enhance the initial survival of cryopreserved fat grafts, their long-term benefits appear limited, suggesting that further research is needed to explore their clinical application.
Article Synopsis
- Lying-ear deformity is an ear condition characterized by excessive backward bending and folding, requiring skilled surgical intervention for treatment.
- A new technique using hyaluronic acid injections was tested on 20 patients, showing significant improvement in ear shape without serious complications.
- Post-treatment results indicated increased angles of the ear, better aesthetic scores, and high patient satisfaction, with strong reliability in grading outcomes.
The selection of hyaluronic acid when treating with the nasolabial fold: A meta-analysis.
J Cosmet Dermatol
February 2022
Background: Hyaluronic acid (HA) gel is a widely used dermal filler for the correction of facial volume loss. The relationship between the characteristics of HA and clinical efficacy remains unclear. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of monophasic and biphasic HA in the treatment of nasolabial folds (NLFs).
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