Publications by authors named "Jun-Nong Ke"
Objectives: To explore the molecular characteristics of rpoB, encoding β-subunit of DNA-directed RNA polymerase, and unravel the link to rifabutin-resistance in patients with refractory Helicobacter pylori infection.
Methods: From January 2018-March 2021, a total of 1590 patients were screened for eligibility to participate in the study. Patients with refractory H.
Article Synopsis
- Amoxicillin resistance in Helicobacter pylori is linked to specific mutations in the penicillin-binding protein-1A (PBP-1A), but the exact mutations responsible are not fully understood.
- The study investigated patients with ongoing H. pylori infections after multiple treatment attempts by analyzing gastric biopsy samples to identify resistant strains and their genetic mutations.
- Results showed that 17 out of 39 cultured H. pylori isolates were amoxicillin-resistant, with multiple PBP-1A mutations present, suggesting a strain-specific mechanism for resistance, highlighting a need for better diagnostic tools in managing such infections.*