Publications by authors named "Jun-Ming Qiu"
Article Synopsis
- Small molecular RNAs like microRNA (miRNA) and small interfering RNA (siRNA) are crucial in regulating gene expression, especially in cancer diagnostics and treatment.* -
- miRNAs are involved in posttranscriptional regulation, while siRNAs can silence specific genes and inhibit tumor development by targeting proto-oncogenes.* -
- Nanoparticles can protect small RNAs from degradation by RNAase, making them effective carriers for delivering these molecules in cancer therapies; the review covers their benefits, limitations, and applications.*
The detection of nucleobases, the informational subunits of DNA and RNA, in several meteorites suggests that these compounds of biological interest were formed via astrophysical, abiotic processes. This hypothesis is in agreement with recent laboratory studies of irradiation of pyrimidine in H2O-rich ices with vacuum UV photons emitted by an H2-discharge lamp in the 6.9-11.
View Article and Find Full Text PDFBackground: Heatstroke is generally considered as a syndrome of hyperthermia associated with systemic inflammation leading to multiorgan dysfunction. High mobility group box-1 protein (HMGB1) has recently been identified as a late mediator of systemic inflammation inducing multiorgan dysfunction. Elevation of plasma HMGB1 in heatstroke has been observed in animals, but there is no data available about its changes in heatstroke patients.
View Article and Find Full Text PDF[Role of assessment and monitoring of human leucocyte antigen-DR on CD14+ monocyte in postoperative infection in patients after orthotopic liver transplantation].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
January 2010
Objective: To investigate the changes in expression level of human leucocyte antigen-DR (HLA-DR) on CD14(+) monocyte (CD14(+)/HLA-DR) in the patients after orthotopic liver transplantation, and its role in monitoring postoperative infection.
Methods: Sixty-three patients with liver transplantation were divided into three groups, non-infection group with 47 cases, infection group with 10 cases and septic shock group with 6 cases [according to the definition of septic shock of American College of Chest Physicians/Society for Critical Care Medicine (ACCP/SCCM)]. CD14(+)/HLA-DR expression ratio was assessed with flow cytometer, and its clinical implication was evaluated by receiver operating characteristic (ROC) curve assay.