Publications by authors named "Jun-Liang Chang"
Hepatitis E is an emerging zoonotic disease, posing a severe threat to public health in the world. Since there are no specific treatments available for HEV infection, it is crucial to develop vaccine to prevent this infection. In this study, the truncated ORF2 encoded protein of 439aa∼617aa (HEV3-179) from HEV CCJD-517 isolates was expressed as VLPs in E.
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- - The study focused on enhancing the sensitivity of A375·S2 cells to interleukin-1 (IL-1) by co-expressing the IL-1 receptor (IL-1R1) and its co-receptor (IL-1R1AcP) genes, demonstrating successful expression using laser scanning confocal microscopy.
- - Quantitative PCR (qPCR) analysis showed a favorable gene ratio of 4.57:1, and after co-transfection, both qPCR and Western blotting indicated a significant increase in protein levels.
- - MTS assays confirmed that the co-transfected A375·S2 cells exhibited noticeably heightened sensitivity to IL-1β, suggesting the potential for this cell