Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.

Ethnopharmacological Relevance: Physalis angulata L., a traditional Chinese medicine called "Kuzhi" in China, was used traditionally to treat liver diseases (eg. icterus, hepatitis) as well as malaria, asthma, and rheumatism.

Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.

Liver fibrosis is the initial pathological process of many chronic liver diseases. Targeting hepatic stellate cell (HSC) activation is an available strategy for the therapy of liver fibrosis. We aimed to explore the anti-liver fibrosis activity and potential mechanism of phomopsterone B (PB) in human HSCs.

Three New Selaginellin Derivatives from Selaginella pulvinata and Their α-Glucosidase Inhibitory Activity.

Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR-ESI-MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol-trimmed skeleton.

New Meroterpenoid and Isocoumarins from the Fungus MST1-15 Collected from Coal Area.

Three new compounds including a meroterpenoid () and two isocoumarins ( and ), together with thirteen known compounds (, ) were isolated from the metabolites of MST1-15. Their structures were identified by a combination of spectroscopic analysis. The absolute configuration of compound was elucidated on the basis of experimental and electronic circular dichroism calculation, and compounds and were determined by Mo(OAc)-induced circular dichroism experiments.