Publications by authors named "Jun-Lan Lv"
We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS "meets" RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions.
View Article and Find Full Text PDFObjective: Leigh syndrome (LS) is a heterogeneous neurodegenerative disease and the most frequent pediatric manifestation of mitochondrial disease. In the largest patient collection to date, this study aimed to provide new insights into the clinical and genetic spectrum of LS, defect-specific associations, and predictors of disease course and survival.
Methods: Clinical, metabolic, neuroimaging, onset, and survival data were collected from the medical records of 209 patients referred to the Beijing Children's Hospital with symmetrical basal ganglia and/or brainstem neuroimaging changes indicative of LS by 30 centers from the Chinese network of mitochondrial disease (mitoC-NET) between January 2013 and July 2021 for exploratory analysis.
Background: To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China.
Methods: This 26-week, single arm, multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment. Enrolled patients received OXC oral suspension treatment for 26 weeks.
Article Synopsis
- Herpetrione (HPE), a new antiviral compound from Herpetospermum caudigerum, has low oral bioavailability due to poor water solubility, necessitating the formulation of nanosuspensions to improve its effectiveness.
- The study produced HPE nanosuspensions using high pressure homogenization and evaluated their characteristics, including particle size, zeta potential, and dissolution rates, through various analytical techniques.
- Results showed that the nanosuspensions had smaller particle sizes, increased dissolution rates, and significantly improved antiviral activity against HBV compared to the coarse form of HPE, indicating that this formulation could enhance oral delivery of poorly bioavailable drugs.
Article Synopsis
- The study investigates how liver injury affects the pharmacokinetics of 6,7-dimethoxycoumarin in rats treated with Yinchenhao Decoction (YCHD) using ultra pressure liquid chromatography (UPLC).
- Following the induction of liver damage with ANIT, results showed significant changes in the drug's concentration and metabolism in the blood.
- The findings suggest that liver injury enhances drug absorption but reduces its clearance, potentially leading to higher drug accumulation in the body.