A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.

The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, or the therapeutic potential of isoform-specific targeting. To systematically compare the impact of individual catalytic functions of HDAC1, HDAC2 and HDAC3, we generated human HAP1 cell lines expressing catalytically inactive HDAC enzymes.

Serum miR-632 is a potential marker for the diagnosis and prognosis in laryngeal squamous cell carcinoma.

It has been demonstrated that miRNAs play critical roles in the tumorigenesis and progression of various tumors. The purpose of this research was to determine the serum miR-632 levels in patients with laryngeal squamous cell carcinoma (LSCC) and to investigate its diagnostic and prognostic value. We detected serum miR-632 levels in 162 LSCC patients and 42 healthy volunteers.