Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications.

Ionic complexes of electrostatically charged biomacromolecules are key players in various biological processes like nucleotide transportation, organelle formation, and protein folding. These complexes, abundant in biological systems, contribute to the function, responsiveness, and mechanical properties of organisms. Coherent with these natural phenomena, hydrogels formed through the complexation of oppositely charged polymers exhibit unique attributes, such as rapid self-assembly, hierarchical microstructures, tunable properties, and protective encapsulation.

CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p.

Osteosarcoma (OS) is a malignant bone tumour that commonly occurs in paediatric and adolescent patients. Currently, effective therapy for OS remains elusive due to poor patient survival rates. In this study, we observed significantly elevated expressions of circTUBA1C in OS tumours and cells.

Association between the dietary literacy of children's daily diet providers and school-age children's nutritional status and eating behaviours: a cross-sectional study.

Background: Overweight and obesity rates have increased rapidly in Chinese school-age children, and previous studies have indicated that poor dietary literacy can lead to unhealthy eating behaviours. However, few studies have investigated the association between the dietary literacy of daily diet providers and the eating behaviours and nutritional status of school-age children raised by the providers. Thus, we aimed to explore this association.

Psychological Resilience Mediates the Association Between Childhood Maltreatment and Self-Harm Phenotype in Chinese Early Adolescents.

Self-harm (SH) increases significantly in early adolescence with great variability, and childhood maltreatment (CM) contributes to this increase. Understanding the developmental pathway from CM to SH could provide clues for SH prevention. This study used latent class analysis (LCA) to detect the phenotype of SH and explored the role of psychological resilience in the pathway from the CM to SH phenotype among 5724 early adolescents (52.

Childhood Adversity Phenotypes and Risky Health Behaviors among Chinese Adolescents: Extending the Concept of Adversity.

Objective: To present an approach to phenotyping ACEs and explore the association between ACEs and adolescent health risky behaviors based on the social context of China.

Methods: Totally, 5,726 adolescents aged 12-18 years were investigated about their ACEs in the family, peer, school, and personal domains and the occurrence of six types of risky health behaviors (i.e.

Injectable Hybrid-Crosslinked Hydrogels as Fatigue-Resistant and Shape-Stable Skin Depots.

Injectable hydrogels have gained considerable attention, but they are typically mechanically weak and subject to repeated physiological stresses in the body. Herein, we prepared polyurethane diacrylate (EPC-DA) hydrogels, which are injectable and can be photocrosslinked into fatigue-resistant implants. The mechanical properties can be tuned by changing photocrosslinking conditions, and the hybrid-crosslinked EPC-DA hydrogels exhibited high stability and sustained release properties.

The Relationship Between Child Sexual Abuse and Sexual Dysfunction in Adults: A Meta-Analysis.

Child sexual abuse (CSA) has been recognized as a risk factor for sexual dysfunction and has attracted increasing attention. However, controversies remain regarding related research. The aim is to calculate the pooled effect size estimate for the correlation between CSA and sexual dysfunction in adults by meta-analysis.

Dynamic Grafting of Carboxylates onto Poly(Vinyl Alcohol) Polymers for Supramolecularly-Crosslinked Hydrogel Formation.

Supramolecular hydrogels have attracted considerable interest due to their unique stimuli-responsive and self-healing properties. However, these hydrogel systems are usually achieved by covalent grafting of supramolecular units onto the polymer backbone, which in turn limits their reprocessability. Herein, we prepared a supramolecular hydrogel system by forming dynamic covalent crosslinks between 4-carboxyphenylboronic acid (CPBA) and polyvinyl alcohol (PVA).

Psychological adjustment mediating the relationship between childhood maltreatment and borderline personality features among Chinese early adolescents.

Background: A strong link between childhood maltreatment (CM) and borderline personality features (BPF) has been consistently demonstrated. However, little is known about the role of psychological adjustment (PA) as a mediator of this relationship. The purpose of the study was to explore the mediating role of PA in the CM-BPF linkage in a large sample of early adolescents.

Exploring the correlates of homicidal ideation in Chinese early adolescents: A network analysis.

Background: Adolescent homicide rates have aroused global concern and better understanding of factors relating to homicidal ideation is critical. This study aimed to explore the correlates of homicidal ideation in a cross-sectional school-based sample of Chinese early adolescents.

Methods: The data were obtained from the cross-sectional project 'Health and Risky Behaviors among Middle School Students in Anhui Province, China', which was conducted in November 2020.

Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine.

Polyelectrolyte hydrogels are emerging materials for tissue engineering and regenerative medicine applications due to their tunable biochemical properties, electrical conductivity, biocompatibility and similar network structure to the extracellular matrix in mammalian bodies. In this review, representative polyelectrolyte hydrogels carrying anionic, cationic, ampholytic, zwitterionic and ionic liquid moieties are systemically cataloged to express their chemical structures and preparation strategies. Recent advance of polyelectrolyte hydrogels in tissue engineering and regenerative medicine for drug delivery, skin healing, bone regeneration, cardiac tissue repair and anti-biofouling coating are also highlighted.

Relationships among adverse childhood experience patterns, psychological resilience, self-esteem and depressive symptoms in Chinese adolescents: A serial multiple mediation model.

Adverse childhood experiences (ACEs) and adolescent depression are both prevalent social problems that can increase the risk of several negative health consequences throughout life. The original definition of ACEs misdirects the focus of intervention efforts for ACEs to only family dysfunction and parenting practices. We used a broader definition of ACEs and a latent class analysis (LCA) model to examine ACE patterns, aiming to overcome the shortcomings of cumulative and single adversity approaches based on the special social context of China.

Bidirectional associations among school bullying, depressive symptoms and sleep problems in adolescents: A cross-lagged longitudinal approach.

Background: Adolescence is a life stage with a high risk of depression, sleep disorders and school bullying. The aim of this study is to examine the longitudinal relationships between school bullying (bullying victimization and bullying perpetration), depressive symptoms and sleep problems among adolescents and to consider whether the direct pathways vary by gender.

Methods: The study included 1687 7th grade students (60.

Childhood trauma and depression in college students: Mediating and moderating effects of psychological resilience.

Purpose: Not all young people who have experienced childhood abuse and neglect will become depressed or have the same degree of depression. Psychological resilience may probably lead to part of the difference according to previous studies. To observe the association between childhood abuse and neglect and depression and analyze whether psychological resilience has mediating and moderating effects on this association.

Childhood abuse and borderline personality disorder features in Chinese undergraduates: the role of self-esteem and resilience.

Background: Although childhood abuse is considered to be related to borderline personality disorder (BPD), few studies have elaborated on the mediating role of self-esteem and resilience in it. Thus, the present study aimed to explore the potential mediating role of resilience and self-esteem between childhood abuse and BPD.

Methods: This cross-sectional study was conducted with 4034 college students in Anhui Province, China.

Synthesis of vinyl iodide chain-end polymers organocatalyzed chain-end transformation.

In the presence of alkynes (CH[triple bond, length as m-dash]C-R2), iodide chain-end polymers (Polymer-I) were successfully transformed to vinyl iodide chain-end polymers (polymer-CH[double bond, length as m-dash]CR2-I) in a single step via organocatalysis. This reaction is completely metal-free and easy to carry out without using special reagents or special conditions. The polymers encompassing polyacrylates and polymethacrylate, and additional functionalities (e.

Comparative Study on Viscoelastic Evaluation Methods of Polymer Materials Based on Ultrasonic Method.

Rubber, as a kind of macromolecular material often used in large ships, aviation, aerospace, and other fields, has remarkable viscoelasticity at room temperature. Therefore, it is of great significance to evaluate the viscoelastic properties of polymer composites. In this paper, four kinds of rubber materials are taken as research objects.

Study on the Viscoelasticity Measurement of Materials Based on Surface Reflected Waves.

The reflected waves received from ultrasonic waves propagating in materials contain information that constitutes the physical properties, material composition, defects, and degradation states. When measuring the dynamic viscoelasticity, the traditional bottom reflection method (BRM) cannot be used to measure the bottom irregular samples. In this paper, the storage modulus, loss modulus, and loss tangent are extracted by the surface reflection method (SRM) to evaluate the elastomer sample viscoelasticity.