Osteoblast response to titanium surfaces coated with strontium ranelate-loaded chitosan film.

Purpose: Improving the peri-implant bone quality has notable clinical value in cases of osteoporosis following implant insertion.

Materials And Methods: In this study, strontium ranelate-loaded chitosan film was produced on a titanium surface in different concentrations of strontium ranelate (SR) (0, 2, 20, 40, and 80 mmol/L of the strontium ion [Sr2+]) with the expectation of utilizing the bone healing-enhancement effect of Sr2+. The physicochemical properties of SR-loaded chitosan films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR).

Masticatory efficiency and oral health-related quality of life with implant-retained mandibular overdentures.

Objectives: To evaluate masticatory efficiency (ME) and oral health-related quality of life (OHRQoL) in patients rehabilitated with implant-retained mandibular overdentures.

Methods: In this randomized controlled clinical trial, 50 edentulous patients visiting the Implant Center and Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu, China between June 2010 and June 2012 were selected and received 2 implant-retained mandibular overdenture treatments. All patients were rehabilitated with maxillary complete dentures.

Single implant in the mandibular molar region of edentulous patient.

Implant-retained overdentures are a valid treatment option for edentulous patients, especially for patients with severe alveolar ridge atrophy. A central single implant is considered adequate to retain an overdenture in the edentulous mandible. However, for some patients, there is no sufficient bone height, or width in the interforaminal region of the mandible for insertion of the implant.

Physicochemical, pharmacologic, and in vitro cellular effects of loading collagen membranes with zoledronic acid.

Purpose: There is a need for improved methods of reducing peri-implant bone loss. This study evaluated the structural, drug loading, drug release, and in vitro characteristics of collagen membranes impregnated with zoledronic acid (ZA).

Materials And Methods: Two commercially available collagen barrier membranes (Bio-Gide and BME-10X) were loaded with ZA.

[Zoledronic acid incorporated in chitosan/calcium phosphate ceramic: characterization and in vitro response of osteoblast cells].

Objective: To develop a new local delivery system, zoledronic-acid-loaded chitosan/calcium phosphate ceramic, and to determine its characterization and in vitro response of osteoblast cells.

Methods: Zoledronic-acid-loaded chitosan/calcium phosphate ceramic were prepared by solution casting method at a concentration of 10(-5), 10(-4), and 10(-3) mol/L, respectively. The physicochemical properties of the resulting materials were determined using SEM and FTIR.

Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts.

Bone-forming osteoblasts have been recently reported capable of expressing the critical co-stimulatory molecule CD40 upon exposure to bacterial infection, which supports the unappreciated role of osteoblasts in modulating bone inflammation. Recent studies highlight the anti-inflammatory potential of glycogen synthase kinase-3β (GSK-3β) inhibitors; however, their effect on osteoblasts remains largely unclear. In the present study, we showed that treatment with SB216763, a highly specific GSK-3β inhibitor, resulted in a dose-dependent decrease in the mRNA and protein expression of CD40, as well as production of pro-inflammatory cytokines IL-6, TNF-α and IL-1β, in the Porphyromonas gingivalis-lipopolysaccharide (LPS)-stimulated murine osteoblastic-like MC3T3-E1 cells.

[Construction and analysis of one kind of chitosan-coated BMP-2 nanoparticles as genetic carrier].

Objective: To construct an excellent kind of chitosan-coated BMP-2 nanoparticles as genetic carrier.

Methods: Chitosan-coated BMP-2 nanoparticles as genetic carrier, including C-B50 group, C-B100 group and C-B200 group, were constructed through re-coacervation and gene recombination methods. This carrier was studied by using morphological observation, enveloping test, anti- DNase I digested test and MTT assay.

[The investigation patients' general knowledge about artificial teeth prosthetics].

Objective: To get the information of patients' understand to the knowledge of artificial teeth prosthetics, provide reference for the propaganda of the prosthetic knowledge.

Methods: 500 patients were chosen as the research objects. The survey about patients' understand to the knowledge of artificial teeth prosthetics was made with a reasonable questionnaire designed by us.