Publications by authors named "Jun-Jiang Sun"
[Study on the Therapeutic Effect of Lenalidomide on Hemophilic Arthropathy].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2022
Article Synopsis
- The study investigates how lenalidomide affects human fibroblast-like synovial cells (HFLS) and its therapeutic potential for treating hemophilic arthropathy in a mouse model of hemophilia A.
- In laboratory tests, lenalidomide was shown to reduce HFLS cell growth and pro-inflammatory cytokine levels, while promoting cell death, especially at lower concentrations.
- In animal experiments, lenalidomide administration significantly improved joint health by decreasing inflammation and pathological changes compared to untreated mice, indicating its protective effects against hemophilic arthritis.