Publications by authors named "Jun-Hyeong You"

The vascular network contributes to the development of follicles. However, the therapeutic mechanism between vascular remodeling and ovarian functions is still unclear. Therefore, we demonstrated whether increased by placenta-derived mesenchymal stem cells (PD-MSCs) improves ovarian function in an ovariectomized rat model via vascular remodeling by signaling activation.

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Article Synopsis
  • Insulin resistance leads to problems with glucose metabolism, which negatively affects ovarian health, but there’s limited research on how glucose affects ovaries.
  • This study aimed to explore how PD-MSCs influence glucose metabolism via the IGFBP2-AMPK signaling pathway and its connection to ovarian function using a rat model with induced injury.
  • Results showed that PD-MSCs significantly boosted the expression of glucose metabolism-related genes and improved ovarian markers and hormone levels, suggesting that IGFBP2 plays a crucial role in enhancing both glucose metabolism and ovarian function.
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Oxidative stress initiates various degenerative diseases, and it is caused by excessive reactive oxygen species (ROS) production. Oxidative stress is a key factor that causes infertility by inducing ovarian dysfunction, characterized by irregular hormone levels, lower quality of mature follicles, and loss of follicles. Hence, stem cell therapy has been actively studied as an approach to overcome the side effects of hormone replacement therapy (HRT) on ovarian dysfunction.

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Mesenchymal stem cells (MSCs) are next-generation treatment in degenerative diseases. For the application of mesenchymal stem cell therapy to degenerative disease, transplantation conditions (e.g.

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Article Synopsis
  • - The study investigates how placenta-derived mesenchymal stem cells (PD-MSCs) overexpressing phosphatase regenerating liver-1 (PRL-1) can improve ovarian function and vascular remodeling in a rat model of ovarian insufficiency.
  • - After conducting a series of experiments where naive and PRL-1-overexpressed PD-MSCs were transplanted into ovariectomized rats, findings showed significant improvements in vascular structures and follicle development in the PRL-1 group compared to controls.
  • - The results highlighted that PRL-1 not only enhanced blood vessel formation but also increased the expression of critical growth factors and genes that aid in vascular remodeling and ovarian tissue health.
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