Publications by authors named "Jun-Hui Tao"
Article Synopsis
- The study investigates immune persistence after switching from trivalent oral poliovirus vaccine (tOPV) to a new immunization schedule (IPV and bOPV) since 2016.
- Blood samples were collected from 1104 participants at various ages to measure antibody levels against polioviruses.
- Results showed that while type 1 and type 3 antibody rates were similar across groups, the 2-specific antibody rates were much higher in the IPV-IPV-tOPV group compared to others, indicating some schedules did not effectively maintain immunity against poliovirus type 2.
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV) at 48 months of age after different primary polio immunization schedules. At 48 months of age, one dose of bOPV was administered, and their poliovirus types 1-3 (PV1, PV2, and PV3, respectively)-specific neutralizing antibody levels were determined. Participants found to be negative for any type of PV-specific neutralizing antibody at 24, 36, or 48 months of age were re-vaccinated with inactivated polio vaccine (IPV).
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