Publications by authors named "Jun-Hao Wan"

Article Synopsis
  • Label-free imaging of nanoscale targets is important for fields like chemistry and life science, as it helps reveal underlying mechanisms.
  • The study introduces a new high-resolution plasmonic imaging method that can effectively image different types of nanomaterials while maintaining detail and speed.
  • This technique allows for real-time monitoring of nanoparticles and can characterize nanomaterials at a single-particle level, making it a valuable tool for research.
View Article and Find Full Text PDF

Background: Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) remains unclear. Therefore, this study surveyed the worth and pathway of SAAL1 in LAC progression and immunity.

View Article and Find Full Text PDF

Immunotherapy can improve the survival of patients with advanced lung squamous cell carcinoma (LUSC). T cytotoxic cells are one of the main members of the immune microenvironment. Herein, we aimed to identify the roles of T-cell cytotoxic markers interleukin 18 (IL18) receptor 1 (IL18R1) in the LUSC progression using bioinformatics, clinical tissue specimen, and cell experiment.

View Article and Find Full Text PDF

The roles and mechanisms of T-cell receptor (TCR)-associated transmembrane adaptor 1 (TRAT1) in lung adenocarcinoma (LAC) have not yet been reported in the relevant literature. Therefore, this study aimed to understand the roles and mechanisms of TRAT1 in LAC using bioinformatics and experiments. TRAT1 expression levels in LAC samples were analysed using various databases.

View Article and Find Full Text PDF

Under the effect of a catalytic amount of Au(I) complex, 4-O-(2-cyclopropylethynyl)benzoyl-(epi)-podophyllotoxins, easily prepared via dehydrative condensation between (epi)-podophyllotoxin and ortho-cyclopropylethynylbenzoic acid, could efficiently couple with a variety of nucleophiles including alcohol, phenol, aniline, and carbon nucleophiles, all to provide (epi)-podophyllotoxin derivatives. Thus, the first catalytic and lignan-activation-based approach for (epi)-podophyllotoxin derivatization was established. Based on the new methodology, as well as the judicious choice of N, AZMB, and Cbz protecting groups, an efficient approach forward was set.

View Article and Find Full Text PDF