Publications by Jun-Hang Jiang

Publications by authors named "Jun-Hang Jiang"

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Luteolin from Flos Chrysanthemi and its derivatives: New small molecule Bcl-2 protein inhibitors.

Can-Hui Zheng Meng Zhang Hui Chen Chong-Qing Wang Min-Min Zhang Jun-Hang Jiang

Bioorg Med Chem Lett

October 2014

Article Synopsis

The over-expression of Bcl-2 proteins is linked to tumor development and contributes to resistance against cancer drugs.
Luteolin, a key component of Flos Chrysanthemi, has been found to bind to and inhibit Bcl-2 proteins.
Research indicates that luteolin and its modified versions can effectively inhibit Bcl-2, suggesting their potential as new anti-tumor agents, particularly in leukemia treatment.

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Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method.

Can-Hui Zheng You-Jun Zhou Ju Zhu Hai-Tao Ji Jun Chen Jun-Hang Jiang

Bioorg Med Chem

October 2007

B-Cell lymphoma-2 (Bcl-2) protein is a new promising target for anticancer drugs. A number of anticancer Bcl-2 inhibitors with diverse chemical structures have been discovered in recent years. In this paper, the flexible docking was performed to determine the binding modes of the representative inhibitors from different structural types.

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