The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents.

Background: Antibiotic resistance is one of the biggest threats to global health today, leading to higher medical costs and increased mortality. Because of the emergence and rapid spread of new resistance mechanisms globally, a growing number of infections are becoming harder to treat as the antibiotics used to treat them become less effective. Therefore, the development of new effective antimicrobial agents is still urgently needed.

[Relation of GSTM1 Polymorphism with Leukemia].

Objective: To investigate the relation of GSTM1 polymorphism in leukemia patients with therapeutic efficacy and the main biological characteristics.

Methods: The GSTM1 genotypes were detected by nested PCR; the remission rate after 1 course of treatment and main biological characteristics at occurrence of leukemia were compared between AL patients with different GSTM1 genotypes, and their relation was analyzed.

Results: The remission rate and partial remission rate after 1 course of treatment in patients with GSTM1-undeleted genotype were no significantly different from those in patients with GSTM1 null genotype (χ=0.

Correlation between p65 and TNF-α in patients with acute myelocytic leukemia.

The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and Pearson's Correlation test was used to demonstrate the correlation between TNF-α and p65 expression levels in AML specimens.

[Association of CD38 gene polymorphism with pathogenesis of chronic myeloid leukemia].

This study was aimed to investigate the distribution of CD38 gene 184 locus allele frequency in chronic myeloid leukemia (CML) and its relation with genetic susceptibility of CML. 100 cases of CML were enrolled in patient group; 200 cases of nonhematologic diseases and nontumor diseases were enrolled in control group. The CD38 gene 184 locus polymorphism was detected by PCR-RFLP, the difference of genotypic frequencies in patient and control groups was analyzed by χ(2) test and Fisher exact probability test, the risk of genotype induced leukemia was expressed by odds ratio (OR) and 95% confidence interval (CI).

Better synchronizability in generalized adaptive networks.

In this paper, to study the interaction between network structure and dynamical property in the context of synchronization, a previously proposed adaptive coupling method is generalized where the coupling strength of a node from its neighbors not only develops adaptively according to the local synchronization property between the node and its neighbors (dynamical part) but also is modulated by its local structure, degree of the node with the form 1/k(i)(alpha) (topological part). We can show both numerically and analytically that the input coupling strength of the network after adaptation displays a power-law dependence on the degree, k(-theta), where the exponent theta is controlled by alpha as theta=(1+alpha)/2. Compared to the original adaptive coupling method, after the addition of modulation, the distribution of the node's intensity is tunable and can be more homogenous with alpha approximately 1, which results in better synchronizability.

[Studies on the chemical constituents of Dryopteris fragrans].

Objective: To study the chemical constituents of Dryopteris fragrans.

Methods: The constituents of CHCl3-soluble portion and ethyl acetate-soluble portion from the alcohol extract were isolated and purified by means of chromatography. All the compounds were identified by their physical characteristics and spectral features.