Underlying disease may increase mortality risk in users of atypical antipsychotics.

Schizophrenia is a group of the most common types of mental illness. Commonly used antischizophrenia drugs all increase mortality to some extent. The increased risk of death in older individuals and patients with dementia using atypical antipsychotics may be due to myocardial damage, increased mobility and increased risk of stroke.

[Large- scale prospective clinical study on prophylactic intervention of COVID-19 in community population using Huoxiang Zhengqi Oral Liquid and Jinhao Jiere Granules].

To scientifically evaluate the intervention effect of Chinese medicine preventive administration(combined use of Huo-xiang Zhengqi Oral Liquid and Jinhao Jiere Granules) on community population in the case of coronavirus disease 2019(COVID-19), a large cohort, prospective, randomized, and parallel-controlled clinical study was conducted. Total 22 065 subjects were included and randomly divided into 2 groups. The non-intervention group was given health guidance only, while the traditional Chinese medicine(TCM) intervention group was given two coordinated TCM in addition to health guidance.

tert-Butyl N-{4-[N-(4-hy-droxy-phen-yl)carbamo-yl]benz-yl}carbamate.

In the title compound, C(19)H(22)N(2)O(4), the dihedral angle between the aromatic rings is 67.33 (2)°. In the crystal, mol-ecules are linked through N-H⋯O and O-H⋯O hydrogen bonds, generating a two-dimensional network lying parallel to (100).

2-Carb-oxy-6-(quinolin-1-ium-8-yl-oxy)benzoate.

In the zwitterionic title compound, C(17)H(11)NO(5), the dihedral angle between the two aromatic rings is 76.90 (7)°. The dihedral angles between the carboxyl groups and the benzene ring are 64.

catena-Poly[[(2-amino-1,3-benzothia-zole-6-carboxyl-ato-κ(2)O,O')(2,2'-bipyridyl-κ(2)N,N')cadmium]-μ-2-amino-1,3-benzothia-zole-6-carboxyl-ato-κ(3)N(1):O,O'].

In the title coordination polymer, [Cd(C(8)H(5)N(2)O(2)S)(2)(C(10)H(8)N(2))](n), the Cd(II) ion is coordinated by a bidentate 2,2-bipyridyl ligand, two O,O'-chelating 2-amino-1,3-benzothia-zole-6-carboxyl-ate (ABTC) ligands and one N-bonded ABTC ligand. The resulting CdN(3)O(4) coordination polyhedron approximates to a very distorted penta-gonal bipramid with one O and one N atom in axial positions. One of the ABTC ligands is bridging to an adjacent metal atom, generating an infinite chain propagating in [100].

Methyl 2-[2-(tert-but-oxy-carbonyl-amino)-1,3-benzothia-zole-6-carboxamido]-acetate.

In the title compound, C(16)H(19)N(3)O(5)S, the dihedral angle between the benzene ring and the carbonyl-amino group is 18.18 (2)°. In the crystal, mol-ecules form centrosymmetric dimers via pairs of N-H⋯N hydrogen bonds.

catena-Poly[lead(II)-bis-(μ-2-amino-1,3-benzothia-zole-6-carboxyl-ato)].

The title complex, [Pb(C(8)H(5)N(2)O(2)S)(2)](n), consists of one Pb(II) ion located on a crystallographic twofold axis and two symmetry-related 2-amino-1,3-benzothia-zole-6-carboxyl-ate (ABTC) ligands. The central Pb(II) ion has a (4 + 2) coordination by four O atoms of the two ABTC ligands and two weaker Pb-S bonding inter-actions (Pb-S secondary bonds) from S atoms of other two neighbouring ABTC ligands. These bonds link the metal ions into zigzag chains along the c axis, which, in turn, aggregate through π-π inter-actions [centroid-centroid distance = 3.

Ethyl 2-(tert-butoxy-carbonyl-amino)-1,3-benzothia-zole-6-carboxyl-ate.

In the crystal of the title compound, C(15)H(18)N(2)O(4)S, inversion dimers are formed by inter-molecular N-H⋯N hydrogen bonds and weak C-H⋯O contacts. These dimers stack up along [100] through inversion-related π-π inter-actions between thia-zole rings [centroid-centroid distance = 3.790 (2) Å] and the thia-zole and benzene rings [centroid-centroid distance = 3.

tert-Butyl N-[6-(N,N-dipropyl-carbamo-yl)-1,3-benzothia-zol-2-yl]carbamate.

The title compound C(19)H(27)N(3)O(3)S, crystallizes with two unique mol-ecules in the asymmetric unit. The benzene ring of each benzothia-zole unit carries a dipropyl-carbamoyl substituent in the 6-position and a tert-butyl carbamate unit on each thia-zole ring. In the crystal structure, inter-molecular N-H⋯N and weak C-H⋯O hydrogen bonds form centrosymmetric dimers.

(4-Aminopyridine-kappaN1)(phthalocyaninato-kappa4N)zinc(II) tetrahydrofuran disolvate.

The title compound, [Zn(C(32)H(16)N(8))(C(5)H(6)N(2))].2C(4)H(8)O, consists of one (phthalocyaninato)zinc (ZnPc) unit, a coordinated 4-aminopyridine (4-ap) molecule and two tetrahydrofuran (THF) solvent molecules. The central Zn atom is (4+1)-coordinated by four isoindole N atoms of the Pc core and by the pyridine N atom of 4-aminopyridine.

The effect of protonation on the spectra and stabilities of alkoxyl substituted phthalocyaninatometals.

The protonation abilities of phthalocyaninatometals (MPcs) increase but their stabilities reduce by the introduction of alkoxyl substituents at alpha position. In the toluene, the order of mono-protonation rate for the tetra-alpha-(2, 2, 4-trimethyl-3-pentoxy)phthalocyaninatometals sorts with the center metals is Zn>Co>Cu>Ni>Fe, which is opposite to the order of their wavelength difference between the Q bands and X bands. However, their mono-protonated species can be decomposed easily at the rate order FePc>CoPc>CuPc>NiPc>ZnPc, analogous to their decomposition abilities in the benzoylperoxide (BPO) oxidation.

[Synthesis and photophysical properties of two kinds of substituted phthalocyaninatozinc].

Two kinds of substituted phthalocyaninatozinc, tetra-beta-phthalimidobutoxy phthalocyaninatozinc (1) and tetra-beta-phthalimidomethyl phthalocyaninatozinc (2), were synthesized by mix melting method, which bear the same phthalimide substituents but the linking of the substituents to the phthalocyanine ring is different. The substituent linking to the phthalocyanine ring is one methylene in ZnPc (2), while the substituents linking to the phthalocyanine ring is four methylenes and one ather in ZnPc (1), in which ather is near by phthalocyanine ring. The absorption and fluorescence spectra and the abilities of singlet oxygen generation of these two phthalocyanines were compared with respect to the effect of different linked fashions.

[Fluorescence spectra and photo-generating rate of singlet oxygen of phthalocyaninatopalladium].

The absorption spectral properties, fluorescence spectral properties and the abilities of photo-generating singlet oxygen of four phthalocyanines, namely tetra-alpha-(2,2,4-trimethyl-3-pentoxy) phthalocyaninatopalladium (zinc) and tetra-alpha-(2,4-diterbutylphenoxy) phthalocyaninatopalladium (zinc), were determined. Experimental results show that the ability of photo-generating singlet oxygen of phthalocyaninatopalladium is similar to that of phthalocyaninatozincx, though palladium(II) is an open shell electron structure and zinc( II ) is a closed shell structure. This may be concerned with a weak flourescence intensity and a strong inter-crossing transition of phthalocyaninatopalladium.

(E)-Methyl 2-[(4-nitro-phen-yl)-hydrazono]-propanoate.

The title compound, C(10)H(11)N(3)O(4), is a condensation product of 4-nitro-phenyl-hydrazine and methyl pyruvate. The complete mol-ecule except for the methyl groups can be considered as a conjugated π system. All non-H atoms are approximately coplanar (r.

2-Benzyl-isoindoline-1,3-dione: a monoclinic polymorph.

In the molecule of the title compound, C(15)H(11)NO(2), the dihedral angle between the ring systems is 81.3 (2)°. In the crystal structure, mol-ecules are held together via C-H⋯O inter-actions.

[Synthesis and UV/Vis spectra of a dialkyloxy substituted phthalocyanine].

A dialkyloxy substituted metal-free phthalocyanine was synthesized by using 3-(2',2',4'-trimethyl-3'-pentoxy)-1,3-diiminoisoindoles and 1,3,3-trichloroisoindolenine as starting materials, and characterized by element analysis, 1H NMR, IR and UV/Vis spectra. The dependences of wavelength of UV/Vis spectra and its split of Q band absorption on the number of substituents and, dielectric constant of solvents are discussed based on the comparison with tetraalkyloxy substituted metal-free phthalocyanine.