Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain.

Objective: It has been reported that D-galactose (D-gal) can model subacute aging, and aluminum (Al) acts as a neurotoxin, but combined effects of them have not been reported. The present work aimed to reveal the effect of combined administration of D-gal and Al in mice and compare the effect of D-gal treatment with that of Al treatment.

Methods: Al was intragastrically administered and D-gal was subcutaneously injected into Kunming mice for 10 consecutive weeks.