Publications by authors named "Jun-Chang Liu"

: Disturbance of tryptophan (Trp) and fatty acid (FA) metabolism plays a role in the pathogenesis of psychiatric disorders. However, quantitative analysis and comparison of plasma Trp metabolites and medium- and long-chain fatty acids (MCFAs and LCFAs) in adult patients with major depressive disorder (MDD) and schizophrenia (SCH) are limited. : Clinical symptoms were assessed and the level of Trp metabolites and MCFAs and LCFAs for plasma samples from patients with MDD ( = 24) or SCH ( = 22) and healthy controls (HC, = 23) were obtained and analyzed.

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Article Synopsis
  • Quetiapine (Que) shows promise not only as an antipsychotic but also in improving cognitive functions and aiding myelin repair, although its impact on brain lipids is still unclear.
  • * In a study using a mouse model with cuprizone (CPZ)-induced demyelination, researchers found significant lipid composition changes in the brain, especially in glycerophospholipids and sphingolipids, with more extensive alterations in the prefrontal cortex compared to the hippocampus and striatum.
  • * Que treatment helped counteract cognitive impairment and normalized some lipid changes caused by CPZ, suggesting that its beneficial effects may be linked to changes in the brain lipidome, offering new insights into
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Dendrobium officinale is a rare and endangered perennial herb in China, which have been used in preparing Chinese tonic medicine for hundreds of years. The severe shortage of this herb and high price have caused that many similar plants were processed as an adulterant and it became difficult to distinguish genuine D. officinale by traditional authentication methods.

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Repetitive transcranial magnetic stimulation (rTMS) may have the potential to prevent depressive relapse. This assessor-blinded, randomized controlled study was designed to evaluate the efficacy and safety of rTMS as a mono- and combination therapy in the prevention of depressive relapse/recurrence. A total of 281 depressed patients who had achieved stable full or partial remission on a 6-month antidepressant (ADP) run-in treatment were randomly assigned to an rTMS (n = 91), ADP (n = 108), or combined (rTMS + ADP, n = 82) treatment group for 12 months.

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