Publications by authors named "Jun-Chang Cui"
Background: Healthcare-associated pneumonia (HCAP) is associated with drug-resistant pathogens and high mortality, and there is no clear evidence that this is due to inappropriate antibiotic therapy. This study was to elucidate the clinical features, pathogens, therapy, and outcomes of HCAP, and to clarify the risk factors for drug-resistant pathogens and prognosis.
Methods: Retrospective observational study among hospitalized patients with HCAP over 10 years.
Background: The number of reported cases, infected with carbepenem resistant Acinetobacter baumannii (CRAb) and multi-drug resistant (MDR) Acinetobacter species had gradually increased in most PLA general hospital wards from April to June in 2007.
Objectives: We have described the investigation of an outbreak of CRAb and MDR Acinetobacter in PLA general hospital, Beijing. The prospective and retrospective findings were identified and analyzed to study the infection causes.
The shortage of effective antibiotics against multidrug-resistant Acinetobacter baumannii (MDR-Ab) has posed great threat to the public health. But the advent of tigecycline gives us new hope. The goal of our research was to assess the clinical efficacy of tigecycline at different doses by using a pharmacokinetic/pharmacodynamic (PK/PD) model which can incorporate pharmacokinetic data of tigecycline from patients with pneumonia and MICs of MDR-Ab from a tertiary hospital.
View Article and Find Full Text PDFCommunity-acquired pneumonia (CAP) is a leading cause of morbidity and mortality throughout the world. To investigate whether moxifloxacin monotherapy is associated with better clinical outcomes than other antibiotics recommended for CAP among adults with mild-to-moderate or severe CAP, we performed a meta-analysis. MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched for randomized control trials (RCTs).
View Article and Find Full Text PDF[Antimicrobial resistance and genotyping of Acinetobacter baumannii in ICU].
Zhonghua Jie He He Hu Xi Za Zhi
September 2010
Article Synopsis
- The study aimed to investigate an outbreak of acinetobacter baumannii in the ICU and assess the antimicrobial resistance of the pathogens to improve prevention strategies.
- Strains of acinetobacter baumannii collected showed resistance to common antibiotics like imipenem and meropenem, while colistin sulphate and tigecycline were highly effective against them.
- The outbreak was attributed to carbapenem-resistant acinetobacter baumannii, with unwashed hands of medical staff likely being a contributing factor, highlighting the importance of hand hygiene in preventing infections.
[Mutant prevention concentrations of fluoroquinolones for Staphylococcus aureus].
Zhonghua Yi Xue Za Zhi
November 2004
Objective: To establish a method to measure mutant prevention concentration (MPC) in vitro, and to measure MPC of fluoroquinolones for staphylococcus aureus.
Methods: The staphylococcus aureus strain ATCC25923 and 20 ciprofloxacin-susceptible clinical isolates were enriched in broth, and the bacterial concentrations were adjusted to 10(10) colony forming units per milliliter. The minimal inhibitory concentration (MIC), MIC for 99% of input cells (MIC99), provisional MPC (MPCpr) and MPC of moxifloxacin, gatifloxacin, pasufloxacin and ciprofloxacin for staphylococcus aureus were determined by agar plates dilution method.